Document Detail

Modulation by thiols of the merocyanine 540-sensitized photolysis of leukemia cells, red cells, and herpes simplex virus type 1.
MedLine Citation:
PMID:  1851305     Owner:  NLM     Status:  MEDLINE    
This paper reports on the role of endogenous and exogenous thiols in the merocyanine 540 (MC 540)-sensitized photoirradiation of L1210 leukemia cells, human erythrocytes, and human Herpes simplex virus type 1. Several measures taken to decrease the intracellular content of glutathione enhanced the cells' sensitivity to MC 540-sensitized photoirradiation while stimulation of glutathione biosynthesis or supplementation of the extracellular or extraviral thiol content decreased the photosensitivity of cells and viruses. Taken together, these data suggest that endogenous and exogenous thiols can modulate the sensitivity of cells and enveloped viruses to MC 540-sensitized photoirradiation. They also pose new questions as to the mechanism of MC 540-sensitized photolysis.
D K Gaffney; J M O'Brien; F Sieber
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Photochemistry and photobiology     Volume:  53     ISSN:  0031-8655     ISO Abbreviation:  Photochem. Photobiol.     Publication Date:  1991 Jan 
Date Detail:
Created Date:  1991-06-10     Completed Date:  1991-06-10     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376425     Medline TA:  Photochem Photobiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  85-92     Citation Subset:  IM    
Department of Biochemistry, Medical College of Wisconsin, Milwaukee 53226.
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MeSH Terms
Cell Line
Erythrocytes / drug effects*,  radiation effects
Glutathione / metabolism
Leukemia L1210 / metabolism
Pyrimidinones / pharmacology*
Radiation-Sensitizing Agents / pharmacology*
Simplexvirus / drug effects*,  radiation effects
Sulfhydryl Compounds / pharmacology*
Grant Support
A124927//PHS HHS; CA42734/CA/NCI NIH HHS
Reg. No./Substance:
0/Pyrimidinones; 0/Radiation-Sensitizing Agents; 0/Sulfhydryl Compounds; 58823-12-4/merocyanine dye; 70-18-8/Glutathione

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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