| Modulation by drugs of the release of total tritium and 3H-5-HT from rat hypothalamic slices. | |
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MedLine Citation:
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PMID: 2366876 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The release of total tritium and 3H-5-hydroxytryptamine (5-HT) evoked by electrical stimulation from prelabelled rat hypothalamic slices was studied. Lysergic acid diethylamide (LSD) decreased white methiothepin increased both total tritium and 3H-5-HT overflow. The proportion of total tritium present as 3H-5-HT was equivalent under control conditions and in the presence of methiothepin and slightly increased in the presence of LSD. Whereas the addition of the 5-HT uptake blocker, citalopram, did not modify the evoked release of total tritium, the monoamine oxidase inhibitor, pargyline, decreased it. In the presence of either of these drugs the proportion of 3H-5-HT was increased. In the presence of citalopram, the inhibition by LSD was reduced on both the release of total tritium and of 3H-5-HT. It thus appears that changes in electrically evoked total tritium overflow in general reflect changes in 3H-5-HT release. When uptake inhibitors or monoamine oxidase inhibitors are present in the medium, the situation is, however, more complex and results from experiments measuring only the release of total tritium should be interpreted with caution. |
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Authors:
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C Moret; M Briley |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Naunyn-Schmiedeberg's archives of pharmacology Volume: 341 ISSN: 0028-1298 ISO Abbreviation: Naunyn Schmiedebergs Arch. Pharmacol. Publication Date: 1990 May |
Date Detail:
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Created Date: 1990-08-14 Completed Date: 1990-08-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0326264 Medline TA: Naunyn Schmiedebergs Arch Pharmacol Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 398-403 Citation Subset: IM |
Affiliation:
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Centre de Recherche Pierre Fabre, Castres, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Citalopram / pharmacology* Electric Stimulation Hypothalamus / anatomy & histology, metabolism* Lysergic Acid Diethylamide / pharmacology* Male Methiothepin / pharmacology Pargyline / pharmacology* Rats Rats, Inbred Strains Serotonin / pharmacokinetics* Tritium / pharmacokinetics* |
| Chemical | |
Reg. No./Substance:
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10028-17-8/Tritium; 20229-30-5/Methiothepin; 50-37-3/Lysergic Acid Diethylamide; 50-67-9/Serotonin; 555-57-7/Pargyline; 59729-33-8/Citalopram |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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