Document Detail

Modulation of blood pressure in the Dahl SS/jr rat by embryo transfer.
MedLine Citation:
PMID:  9453359     Owner:  NLM     Status:  MEDLINE    
Gestational hypertension and malnutrition are associated with hypertension and ischemic heart disease in the adult human. The impact of the gestational environment on the adult blood pressure in two well-characterized genetically homogeneous rat strains, the hypertensive SS/jr and normotensive SR/jr, was studied by cross-fostering within 6 hours of birth and by embryo transplantation with the recipient dam nursing the transplanted pups. Systolic blood pressure (BP) was measured by tail-cuff plethysmography twice a week after the age of 7 weeks. The lactational environment (cross-fostering) had no effect on blood pressure. Embryo transfer between like strains had no effect on the development of hypertension, nor did the BP of R transferred to S (RetS) differ from that of normal R or RetR. At 7 weeks of age, the BP of SetR was significantly lower than that of S or SetS (P<.01) and was similar to that of RetR and R. With age, the blood pressures of the S, SetS and SetR increased at approximately the same rate but from a significantly different baseline. Salt-sensitivity in the S and resistance in the R were not altered. The protective effect of the R gestational environment on SetR female BP was abrogated during whelping and lactation. Embryo transfer and cross-fostering did not alter the weight of rats older than 7 weeks. Because the BP of the R dams were significantly lower than that of the S dams, these studies do not distinguish between the effects of the R dams' lower blood pressure per se and hormonal influences of the R uterus on the S blood pressure phenotype.
H M Kubisch; S Mathialagan; E P Gómez-Sánchez
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Hypertension     Volume:  31     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:  1998 Jan 
Date Detail:
Created Date:  1998-02-20     Completed Date:  1998-02-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  540-5     Citation Subset:  IM    
Department of Animal Sciences, University of Missouri-Columbia, Harry S Truman Memorial Veterans Hospital Columbia, 65201, USA.
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MeSH Terms
Aging / physiology*
Aldosterone Antagonists / administration & dosage,  pharmacology
Blood Pressure / drug effects,  physiology*
Cerebral Ventricles / drug effects,  physiology
Embryo Transfer*
Infusions, Parenteral
Rats, Inbred Strains
Sex Characteristics
Spironolactone / administration & dosage,  analogs & derivatives,  pharmacology
Grant Support
Reg. No./Substance:
0/Aldosterone Antagonists; 52-01-7/Spironolactone; 76676-34-1/RU 28318

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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