Document Detail


Modulation of blood pressure in the Dahl SS/jr rat by embryo transfer.
MedLine Citation:
PMID:  9453359     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Gestational hypertension and malnutrition are associated with hypertension and ischemic heart disease in the adult human. The impact of the gestational environment on the adult blood pressure in two well-characterized genetically homogeneous rat strains, the hypertensive SS/jr and normotensive SR/jr, was studied by cross-fostering within 6 hours of birth and by embryo transplantation with the recipient dam nursing the transplanted pups. Systolic blood pressure (BP) was measured by tail-cuff plethysmography twice a week after the age of 7 weeks. The lactational environment (cross-fostering) had no effect on blood pressure. Embryo transfer between like strains had no effect on the development of hypertension, nor did the BP of R transferred to S (RetS) differ from that of normal R or RetR. At 7 weeks of age, the BP of SetR was significantly lower than that of S or SetS (P<.01) and was similar to that of RetR and R. With age, the blood pressures of the S, SetS and SetR increased at approximately the same rate but from a significantly different baseline. Salt-sensitivity in the S and resistance in the R were not altered. The protective effect of the R gestational environment on SetR female BP was abrogated during whelping and lactation. Embryo transfer and cross-fostering did not alter the weight of rats older than 7 weeks. Because the BP of the R dams were significantly lower than that of the S dams, these studies do not distinguish between the effects of the R dams' lower blood pressure per se and hormonal influences of the R uterus on the S blood pressure phenotype.
Authors:
H M Kubisch; S Mathialagan; E P Gómez-Sánchez
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Hypertension     Volume:  31     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:  1998 Jan 
Date Detail:
Created Date:  1998-02-20     Completed Date:  1998-02-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  540-5     Citation Subset:  IM    
Affiliation:
Department of Animal Sciences, University of Missouri-Columbia, Harry S Truman Memorial Veterans Hospital Columbia, 65201, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aging / physiology*
Aldosterone Antagonists / administration & dosage,  pharmacology
Animals
Blood Pressure / drug effects,  physiology*
Cerebral Ventricles / drug effects,  physiology
Embryo Transfer*
Female
Genotype
Humans
Infusions, Parenteral
Male
Pregnancy
Rats
Rats, Inbred Strains
Sex Characteristics
Spironolactone / administration & dosage,  analogs & derivatives,  pharmacology
Grant Support
ID/Acronym/Agency:
HL27255/HL/NHLBI NIH HHS; HL27737/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Aldosterone Antagonists; 52-01-7/Spironolactone; 76676-34-1/RU 28318

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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