| Modulation of blood pressure by substance P: opposite effects of N- and C- terminal fragments on anesthetized rats. | |
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MedLine Citation:
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PMID: 2437424 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Considerable evidence suggests that substance P (SP) may be a transmitter mediating the depressor effects of baroreceptor reflex activation within the brainstem, yet intracerebroventricular administration of SP is reported to result in a pronounced pressor effect. In this study, SP injected into the 4th cerebral ventricle produced a biphasic effect; a brief decrease in blood pressure followed by a lengthy increase. Similar injections of a carboxy-terminal fragment of SP produced only a pressor effect of long duration. Injection of an amino-terminal SP fragment produced only a brief, rapid depressor effect. These results suggest that the amino-terminal sequence of SP may be involved in mediating the depressor effects of baroreceptor activation. |
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Authors:
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M E Hall; F B Miley; J M Stewart |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Life sciences Volume: 40 ISSN: 0024-3205 ISO Abbreviation: Life Sci. Publication Date: 1987 May |
Date Detail:
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Created Date: 1987-06-18 Completed Date: 1987-06-18 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0375521 Medline TA: Life Sci Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1909-14 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anesthesia Animals Blood Pressure / drug effects* Male Peptide Fragments / pharmacology* Pressoreceptors / drug effects, physiology Rats Rats, Inbred Strains Substance P / pharmacology* Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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HL 33534/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Peptide Fragments; 33507-63-0/Substance P; 72226-88-1/substance P (1-7) |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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