Document Detail

Modulation of birthweight through gestational age and fetal growth.
MedLine Citation:
PMID:  8640963     Owner:  NLM     Status:  MEDLINE    
Several factors are known to affect birthweight and their effects are variously mediated through gestational duration or through fetal growth conditional on this gestation. In order to quantify independent associations of birthweight conditional and unconditional on gestational age, all 2538 mothers of singleton babies delivered during 1993 in two Maternity Hospitals in Athens were interviewed and their obstetric records abstracted. Birthweight was modelled as outcome variable through multiple regression including 32 potentially predictive factors. The regression model was fitted with and without gestational age as an additional independent variable in order to apportion birthweight associations into those independent of, or mediated through, gestational length. The factors studied were found to be classifiable into the following categories: factors associated with birthweight mostly through increases in gestational duration, either positively (age at menarche, long menstrual cycles, parity 4 or higher), or negatively (single motherhood, maternal age, tobacco smoking); those associated with birthweight mostly through increase of birthweight conditional on gestational duration, either positively (male gender, short menstrual cycles, maternal pre-pregnancy weight, anaemia, oedema) or inversely (employment during pregnancy, stillbirth, primiparity, pregnancy induced hypertension, coffee drinking); and those associated with birthweight through apparently dual effects, either positively (maternal education) or inversely (perceived stress, bleeding during pregnancy). The other studied factors were not demonstrably related to birthweight in this data set. Identification and quantification of these relations is useful for understanding underlying physiological and pathophysiological processes and for increasing specificity in exploring the association of birthweight with adult onset diseases, like coronary heart disease or cancer.
E Petridou; D Trichopoulos; K Revinthi; D Tong; E Papathoma
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Child: care, health and development     Volume:  22     ISSN:  0305-1862     ISO Abbreviation:  Child Care Health Dev     Publication Date:  1996 Jan 
Date Detail:
Created Date:  1996-07-16     Completed Date:  1996-07-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7602632     Medline TA:  Child Care Health Dev     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  37-53     Citation Subset:  IM    
Department of Hygiene and Epidemiology, Athens University Medical School, Greece.
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MeSH Terms
Birth Weight*
Fetal Growth Retardation / etiology*,  prevention & control
Gestational Age*
Infant, Low Birth Weight
Infant, Newborn
Infant, Premature, Diseases / etiology*,  prevention & control
Neonatal Screening
Prenatal Exposure Delayed Effects
Reference Values
Risk Factors

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