| Modulation of arthritis in rats by Toxicodendron pubescens and its homeopathic dilutions. | |
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MedLine Citation:
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PMID: 21784329 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND: Toxicodendron pubescens P. Mill (Anacardiaceae) known in homeopathy as Rhus toxicodendron (Rhus tox) is used as an anti-inflammatory medicine in homeopathic practice. In this study, Rhus tox in its crude form and homeopathic dilutions (3cH, 6cH, 30cH, 200cH) was evaluated for effects on Complete Freund's Adjuvant (CFA) induced arthritis in rats. METHOD: We assessed the severity of arthritis through observations including inflammatory lesions, body and organ weight and hematological parameters including C-reactive protein (CRP). Blinded radiological analysis of the affected joints and pain intensity determination was also carried out. RESULTS: Rhus tox protected rats from CFA-induced inflammatory lesions, body weight changes and hematological alterations. Rhus tox protected against radiological joint alterations due to arthritis. Arthritic pain scores were also favorably affected by Rhus tox. All the dilutions of Rhus tox including crude form showed anti-arthritic activity. The maximum protective effect was evident in the crude form at 10mg/kg/day, by mouth. CONCLUSION: This study supports claims in the homeopathic literature on the role of Rhus tox and its ultra dilutions in the treatment of arthritis and associated pain. Further study is needed to explain this anti-arthritic effect of Rhus tox. |
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Authors:
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Chandragouda Raosaheb Patil; Ashish Devidas Rambhade; Ramchandra Baburao Jadhav; Kalpesh Ramdas Patil; Vishal Kumar Dubey; Bhavin Maheshkumar Sonara; Sanjay S Toshniwal |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Homeopathy : the journal of the Faculty of Homeopathy Volume: 100 ISSN: 1476-4245 ISO Abbreviation: Homeopathy Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-07-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101140517 Medline TA: Homeopathy Country: Scotland |
Other Details:
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Languages: eng Pagination: 131-7 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 The Faculty of Homeopathy. Published by Elsevier Ltd. All rights reserved. |
Affiliation:
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R. C. Patel Institute of Pharmaceutical Education and Research, Karvand Naka, Shirpur 425 405, Dhule, Maharashtra, India. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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