Document Detail


Modulation of antioxidant defence system by dietary fat in rats intoxicated with o-toluidine.
MedLine Citation:
PMID:  12540036     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
o-Toluidine was administered to rats in the diet for four weeks at levels approximately 40, 80 and 160 mg/kg b.w. per day. Two types of diet have been used, standard (4% fat) and high fat (14% fat). Activity of antioxidant enzymes, level of glutathione and thiobarbituric acid reactive substances were measured in liver. Glutathione peroxidase was significantly increased in all treated groups while glutathione S-transferase and glutathione reductase were elevated in rats fed high-fat diet. o-Toluidine slightly enhanced catalase activity regardless of the kind of diet. Superoxide dismutase was the only enzyme whose activity was lowered in almost all treated groups. Enzymatic and nonenzymatic microsomal lipid peroxidation was enhanced 2- to 3-fold in both diet groups. Reduced glutathione level in liver was 2.3- to 4.0-fold increased in all treated groups. Our findings indicate that free radical processes can be involved in the toxic effects of o-toluidine and dietary fat can modify the response of some antioxidant enzymes to this compound.
Authors:
J Jodynis-Liebert; M Murias
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Human & experimental toxicology     Volume:  21     ISSN:  0960-3271     ISO Abbreviation:  Hum Exp Toxicol     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2003-01-23     Completed Date:  2003-06-03     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  9004560     Medline TA:  Hum Exp Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  659-65     Citation Subset:  IM    
Affiliation:
Department of Toxicology, Karol Marcinkowski University of Medical Sciences, ul. Dojazd 30, 60-631 Poznań, Poland. liebert@am.poznan.pl
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Animals
Antioxidants / metabolism*
Carcinogens / administration & dosage,  toxicity*
Catalase / metabolism
Dietary Fats / administration & dosage*
Dose-Response Relationship, Drug
Enzymes / metabolism
Glutathione / metabolism
Glutathione Peroxidase / metabolism
Glutathione Transferase / metabolism
Lipid Peroxidation*
Liver / drug effects,  enzymology
Male
Microsomes, Liver / drug effects,  enzymology
Rats
Rats, Wistar
Thiobarbituric Acid Reactive Substances / metabolism
Toluidines / administration & dosage,  toxicity*
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Carcinogens; 0/Dietary Fats; 0/Enzymes; 0/Thiobarbituric Acid Reactive Substances; 0/Toluidines; 70-18-8/Glutathione; 95-53-4/2-toluidine; EC 1.11.1.6/Catalase; EC 1.11.1.9/Glutathione Peroxidase; EC 2.5.1.18/Glutathione Transferase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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