Document Detail

Modulation of antioxidant activities and immune response by food restriction in aging Fisher-344 rats.
MedLine Citation:
PMID:  7599247     Owner:  NLM     Status:  MEDLINE    
Food restriction delays the loss of several cellular immune functions, retards the onset of many diseases during aging and, consequently, extends life span significantly in laboratory rodents. The present study was undertaken to determine whether the age-associated loss in immune function is linked to changes in microsomal and mitochondrial membranes of spleens in Fischer-344 (F-344) male rats. In this study, we determined cytosolic superoxide dismutase activity (SOD), fluidity and cholesterol content in the splenic microsomal and mitochondrial membranes, and DNA synthesis and IL-2 production in spleen cells from young and old ad libitum-fed (AL) and food restricted (FR) rats. The results show that proliferative response to phytohemagglutinin (PHA) and concanavalin A (Con-A) was significantly higher in the spleen cells of 18-month- and 24-month-old FR rats, as compared to their age-matched AL controls. Cytosolic SOD activity in the 24-month-old AL rats decreased by 28% as compared to 6-month-old AL rats, whereas in FR old rats, the loss was only 12%, suggesting that food restriction prevents loss in cytosolic SOD activity in spleens. Our data are consistent with the notion that food restriction modulates loss in immune response of splenocytes by maintaining both cytosolic SOD activity and membrane fluidity during aging.
D S Byun; J T Venkatraman; B P Yu; G Fernandes
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Aging (Milan, Italy)     Volume:  7     ISSN:  0394-9532     ISO Abbreviation:  Aging (Milano)     Publication Date:  1995 Feb 
Date Detail:
Created Date:  1995-08-10     Completed Date:  1995-08-10     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9102503     Medline TA:  Aging (Milano)     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  40-8     Citation Subset:  IM    
Department of Medicine, University of Texas Health Science Center, San Antonio 78284-7874, USA.
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MeSH Terms
Aging / immunology*,  metabolism
Antioxidants / analysis*
Cholesterol / analysis
Diet, Reducing*
Fatty Acids / analysis
Interleukin-2 / biosynthesis
Lymphocyte Activation
Membrane Fluidity
Membrane Lipids / chemistry
Rats, Inbred F344
Superoxide Dismutase / metabolism*
Grant Support
P0-1 AG01188/AG/NIA NIH HHS; R01-AG-03417/AG/NIA NIH HHS; R01-AG-10531/AG/NIA NIH HHS
Reg. No./Substance:
0/Antioxidants; 0/Fatty Acids; 0/Interleukin-2; 0/Membrane Lipids; 57-88-5/Cholesterol; EC Dismutase

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