Document Detail


Modulation of allospecific CTL responses during pregnancy in equids: an immunological barrier to interspecies matings?
MedLine Citation:
PMID:  10201987     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Maternal immune recognition of the developing conceptus in equine pregnancy is characterized by the strongest and most consistent alloantibody response described in any species, a response directed almost exclusively against paternal MHC class I Ags. This work investigated the cellular immune response to paternal MHC Ags in pregnant and nonpregnant horses and donkeys, and in horses carrying interspecies hybrid mule conceptuses. We observed profound decreases in classical, MHC-restricted, CTL activity to allogeneic paternal cells in peripheral blood lymphocytes from both horse mares and donkey jennets carrying intraspecies pregnancies, compared with cells from nonpregnant controls. This is the first evidence in a randomly bred species for a generalized systemic shift of immune reactivity away from cellular and toward humoral immunity during pregnancy. Surprisingly, mares carrying interspecies hybrid mule conceptuses did not exhibit this transient, pregnancy-associated decrease in CTL activity. The failure of interspecies pregnancy to down-regulate cellular immune responses may be a heretofore-unrecognized, subtle barrier to reproductive success between species.
Authors:
J M Baker; A I Bamford; D F Antczak
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of immunology (Baltimore, Md. : 1950)     Volume:  162     ISSN:  0022-1767     ISO Abbreviation:  J. Immunol.     Publication Date:  1999 Apr 
Date Detail:
Created Date:  1999-05-06     Completed Date:  1999-05-06     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  2985117R     Medline TA:  J Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  4496-501     Citation Subset:  AIM; IM    
Affiliation:
James A. Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA. jmb8@cornell.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Breeding*
Cells, Cultured
Crosses, Genetic
Cytotoxicity Tests, Immunologic / veterinary
Epitopes, T-Lymphocyte / analysis
Equidae / genetics*,  immunology*
Fathers
Female
Histocompatibility Antigens Class I / analysis
Horses
Major Histocompatibility Complex / genetics,  immunology
Male
Mothers
Pregnancy
Pregnancy, Animal / genetics*,  immunology*
Species Specificity*
T-Lymphocytes, Cytotoxic / immunology
Grant Support
ID/Acronym/Agency:
NICHD-15799/HD/NICHD NIH HHS; NICHD-80436/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Epitopes, T-Lymphocyte; 0/Histocompatibility Antigens Class I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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