Document Detail


Modulation of allogeneic immune responses by filgrastim (recombinant human granulocyte colony-stimulating factor) in bone marrow transplantation.
MedLine Citation:
PMID:  8589369     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We examined whether the use of G-CSF would affect the outcome of allogeneic marrow transplantation in humans and mice. Retrospective analysis of 24 patients who had received allogeneic marrow grafts from HLA-identical siblings revealed that the incidence of chronic but not acute graft-versus-host disease (GVHD) was lower in the patients receiving G-CSF than in those not given G-CSF (18% vs. 80%, P = 0.02). There was a difference in serum TNF-alpha levels during the first 3 months after transplant between these two groups. Four out of the ten patients who were not given G-CSF showed elevated serum TNF-alpha levels, whereas there was only one patients with an increased TNF-alpha level among eleven patients who were given G-CSF. With the use of murine acute and chronic GVHD models, we also observed that administration of G-CSF improved the survival of minor GVHD, but not major GVHD, mice. Taken together, these findings suggest that G-CSF down-regulates allogeneic immune responses and is active in modulating alloreactivity in vivo.
Authors:
M Hirokawa; A Kitabayashi; H Niitsu; H Takatsu; A B Miura
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of hematology     Volume:  62     ISSN:  0925-5710     ISO Abbreviation:  Int. J. Hematol.     Publication Date:  1995 Dec 
Date Detail:
Created Date:  1996-03-27     Completed Date:  1996-03-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9111627     Medline TA:  Int J Hematol     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  235-41     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine III, Akita University School of Medicine, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antibody Formation / drug effects
Bone Marrow Transplantation / immunology*
Female
Filgrastim
Granulocyte Colony-Stimulating Factor / therapeutic use*
Humans
Mice
Mice, Inbred BALB C
Recombinant Proteins / therapeutic use
Retrospective Studies
Transplantation, Homologous
Chemical
Reg. No./Substance:
0/Recombinant Proteins; 121181-53-1/Filgrastim; 143011-72-7/Granulocyte Colony-Stimulating Factor

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