| Modulation of age-related NF-kappaB activation by dietary zingerone via MAPK pathway. | |
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MedLine Citation:
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PMID: 20211236 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Zingerone, a major component found in ginger root, has been known as anti-mutagenic and anti-carcinogenic activities that are often associated with its anti-oxidative and anti-inflammatory activities. In recent studies, we examined molecular mechanism of zingerone treatment on pro-inflammatory NF-kappaB activation via the redox-related NIK/IKK and MAPK pathways. Action mechanism of zingerone on NF-kappaB signaling was investigated in aged rat kidney and endothelial cells. The results showed that zingerone had not only the antioxidant effect by constitutive suppression of ROS, but also anti-inflammatory effects by suppression of nuclear factor (NF)-kappaB activation in aged rat. In addition, zingerone treatment suppressed gene activation of pro-inflammatory enzymes, COX-2 and iNOS, which were upregulated with aging through NF-kappaB activation and IKK/MAPK signaling pathway. These experiments strongly indicate that zingerone treatment exerts a beneficial efficacy by suppressing both oxidative stress and age-related inflammation through the modulation of several key pro-inflammatory genes and transcription factors. Thus, the significance of our findings is that the zingerone treatment may provide some preventive measure against chronic inflammatory conditions that underlie many age-related inflammatory diseases, such as metabolic syndrome, cardiovascular disease, dementia, arthritis, diabetes, osteoprosis, and cancers. |
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Authors:
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Mi Kyung Kim; Sang Woon Chung; Dae Hyun Kim; Ji Min Kim; Eun Kyeong Lee; Ji Young Kim; Young Mi Ha; Yun Hee Kim; Jae-Kyung No; Hye Sun Chung; Kun-Young Park; Sook Hee Rhee; Jae Sue Choi; Byung Pal Yu; Takako Yokozawa; Young Jin Kim; Hae Young Chung |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-03-06 |
Journal Detail:
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Title: Experimental gerontology Volume: 45 ISSN: 1873-6815 ISO Abbreviation: Exp. Gerontol. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-03 Completed Date: 2010-08-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0047061 Medline TA: Exp Gerontol Country: England |
Other Details:
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Languages: eng Pagination: 419-26 Citation Subset: IM |
Copyright Information:
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2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Pharmacy, Pusan National University, Busan, South Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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drug effects,
metabolism* Animals Anti-Inflammatory Agents / pharmacology* Antioxidants / pharmacology* Blotting, Western Caloric Restriction Guaiacol / analogs & derivatives*, pharmacology Humans Inflammation / metabolism MAP Kinase Signaling System / drug effects*, physiology Mitogen-Activated Protein Kinases / drug effects, metabolism* NF-kappa B / metabolism*, pharmacology Nitric Oxide Synthase Type II Oxidation-Reduction / drug effects Oxidative Stress / drug effects Rats Rats, Inbred F344 Reactive Oxygen Species / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 0/Antioxidants; 0/NF-kappa B; 0/Reactive Oxygen Species; 122-48-5/zingerone; 90-05-1/Guaiacol; EC 1.14.13.39/Nitric Oxide Synthase Type II; EC 2.7.11.24/Mitogen-Activated Protein Kinases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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