Document Detail

Modulation of the accumulation of inositol phosphates and the mobilization of calcium in aortic myocytes.
MedLine Citation:
PMID:  3215277     Owner:  NLM     Status:  MEDLINE    
In vascular smooth muscle cells the phorbol ester, 12-O-tetradecanoyl phorbol 13-acetate (TPA), a potent activator of C-kinase, inhibited the accumulation of inositol phosphates and the mobilization of calcium produced by several agonists. In the same way, TPA inhibited the fluoride-induced activation of phosphoinositide metabolism. These results suggest a C-kinase action at a post-receptor level. Moreover, the fluoride-induced accumulation of inositol phosphates shows the presence of one or more guanine nucleotide-binding proteins (G-proteins) in the regulation of receptor-phospholipase C coupling. This was confirmed by the use of N-ethylmaleimide and pertussis toxin. These results support the view that, in addition to the induction of sustained contractions, C-kinase can activate negative feedback mechanisms in aortic myocytes.
P Berta; S Phaneuf; P Travo; J C Cavadore
Related Documents :
9862447 - Negative regulation of interleukin-1beta-activated neutral sphingomyelinase by protein ...
6441597 - Functional properties of carbohydrate-depleted tissue plasminogen activator.
7515277 - Lysophosphatidylcholine increases vascular superoxide anion production via protein kina...
8170967 - A faster-acting and more potent form of tissue plasminogen activator.
24401847 - Protein kinase g increases antioxidant function in lung microvascular endothelial cells...
11226577 - Hepatitis c virus core protein potentiates c-jun n-terminal kinase activation through a...
Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of pharmacology     Volume:  153     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1988 Aug 
Date Detail:
Created Date:  1989-03-03     Completed Date:  1989-03-03     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  123-9     Citation Subset:  IM    
Centre de Recherches de Biochimie Macromoléculaire, LP 8402/C.N.R.S., I.N.S.E.R.M./U 249, Faculté de Médecine, Montpellier, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aorta, Thoracic / metabolism
Benzofurans / diagnostic use
Calcium / metabolism*
Ethylmaleimide / pharmacology
Inositol Phosphates / metabolism*
Muscle, Smooth, Vascular / metabolism*
Pertussis Toxin
Sodium Fluoride / pharmacology
Sugar Phosphates / metabolism*
Type C Phospholipases / metabolism
Virulence Factors, Bordetella / pharmacology
Reg. No./Substance:
0/Benzofurans; 0/Inositol Phosphates; 0/Sugar Phosphates; 0/Virulence Factors, Bordetella; 128-53-0/Ethylmaleimide; 7440-70-2/Calcium; 7681-49-4/Sodium Fluoride; 96314-98-6/Fura-2; EC Toxin; EC 3.1.4.-/Type C Phospholipases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Analgesia produced by centrally administered DAGO, DPDPE and U50488H in the formalin test.
Next Document:  Vasopressin and adrenalectomy-induced sensitivity to morphine.