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Modulation of Tthy alloantigen expression in the neonatal mouse. The Tthy-bearing thymocyte is a precursor for the peripheral cells expressing Tind and Tsu.
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MedLine Citation:
PMID:  6129278     Owner:  NLM     Status:  MEDLINE    
The T cell alloantigen Tthyd appears on a subpopulation of thymocytes in mice bearing the Igh-1d or e heavy chain haplotype. Ontogenetic studies have suggested that this antigen precedes the appearance of two other T cell alloantigens in the same linkage group, Tindd and Tsud. The purpose of this study was to determine if the Tthy-bearing cell is a precursor for cells in the periphery expressing Tind and Tsu. CAL-20 mice were treated at 48-h intervals beginning on the day of birth with a monoclonal antibody recognizing Tthy. Tthy alloantigen expression, monitored by cytotoxicity assays, was found to be significantly depressed in the thymuses of treated animals; Tind and Tsu also failed to appear in the periphery. Treatment with anti-Tthy caused no significant changes in frequency or surface intensity in the expression of surface Ig. Thy-1.2, Thy-1.2, and Lyt-2.2, as studied by cytofluorograph analysis. We conclude that the T-thyd-bearing cells in the thymus represent a subpopulation that may be a precursor for Tindd- and Tsud-bearing cells. However, Tthyd-bearing cells are more mature than the Thy-1.2 common T cell precursor, pre-T.
S K Keesee; F L Owen
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of experimental medicine     Volume:  157     ISSN:  0022-1007     ISO Abbreviation:  J. Exp. Med.     Publication Date:  1983 Jan 
Date Detail:
Created Date:  1983-02-25     Completed Date:  1983-02-25     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985109R     Medline TA:  J Exp Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  86-97     Citation Subset:  IM    
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MeSH Terms
Animals, Newborn / immunology
Antibodies, Monoclonal
Antigens, Ly / immunology
Antigens, Surface / immunology*
Antigens, Thy-1
Cell Differentiation
Receptors, Antigen, T-Cell / immunology*
T-Lymphocytes / immunology*
Thymus Gland / cytology,  immunology*
Grant Support
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Antigens, Ly; 0/Antigens, Surface; 0/Antigens, Thy-1; 0/Isoantibodies; 0/Receptors, Antigen, T-Cell

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Journal Information
Journal ID (nlm-ta): J Exp Med
ISSN: 0022-1007
ISSN: 1540-9538
Publisher: The Rockefeller University Press
Article Information
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Print publication date: Day: 1 Month: 1 Year: 1983
Volume: 157 Issue: 1
First Page: 86 Last Page: 97
ID: 2186894
Publisher Id: 83084626
PubMed Id: 6129278

Modulation of Tthy alloantigen expression in the neonatal mouse. The Tthy-bearing thymocyte is a precursor for the peripheral cells expressing Tind and Tsu

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