| Modulation of Pseudomonas aeruginosa lipopolysaccharide-induced lung inflammation by chronic iron overload in rat. | |
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MedLine Citation:
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PMID: 22066700 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Iron constitutes a critical nutrient source for bacterial growth so iron overload is a risk factor for bacterial infections. This study aimed at investigating the role of iron overload in modulating bacterial endotoxin-induced lung inflammation. Weaning male Wistar rats were intraperitoneally injected with saline or iron sucrose (15 mg/kg body weight (bw), 3 times/week, 4 weeks). They were then intratracheally injected with Pseudomonas aeruginosa lipopolysaccharide (LPS) (5 μg/kg bw) or saline. Inflammatory indices were evaluated 4 or 18h post LPS/saline injection. At 4h, LPS-treated groups revealed significant increases in the majority of inflammatory parameters (LPS-binding protein (LBP), immune cell recruitment, inflammatory cytokine synthesis, myeloperoxidase activity and alteration of alveolar-capillary permeability), as compared to control groups. At 18h, these parameters reduced strongly with exception for LBP content and interleukin (IL)-10. In parallel, iron acted as a modulator of immune cell recruitment; LBP, tumor necrosis factor-α, cytokine-induced neutrophil chemoattractant 3 and IL-10 synthesis; and alveolar-capillary permeability. Therefore, Pseudomonas aeruginosa LPS may only act as an acute lung inflammatory molecule and iron overload may modulate lung inflammation by enhancing different inflammatory parameters. Thus, therapy for iron overload may be a novel and efficacious approach for the prevention and treatment of bacterial lung inflammations. |
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Authors:
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Bá V Ng Lê; Hafida Khorsi-Cauet; Véronique Bach; Jérôme Gay-Quéheillard |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-5 |
Journal Detail:
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Title: FEMS immunology and medical microbiology Volume: - ISSN: 1574-695X ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-9 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9315554 Medline TA: FEMS Immunol Med Microbiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved. |
Affiliation:
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Peritox Laboratory EA4285-UMI 01, Faculty of Medicine, Picardy Jules Verne University, 3 rue des Louvels, 80036, Amiens, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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