| Modulation of matrix metalloproteinase and cytokine production by licorice isolates licoricidin and licorisoflavan a: potential therapeutic approach for periodontitis. | |
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MedLine Citation:
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PMID: 20722535 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Background: Inflammatory cytokines and matrix metalloproteinases (MMPs) produced by resident and inflammatory cells in response to periodontopathogens play a major role in the tissue destruction observed in periodontitis, which is a disease that affects tooth-supporting structures. In the present study, we investigate the effects of licorice-derived licoricidin (LC) and licorisoflavan A (LIA) on the secretion of various cytokines and MMPs by human monocyte-derived macrophages stimulated with Aggregatibacter actinomycetemcomitans (previously Actinobacillus actinomycetemcomitans) lipopolysaccharide (LPS). Methods: Macrophages were treated with non-toxic concentrations of LC or LIA before being stimulated with A. actinomycetemcomitans LPS. The secretion of cytokines and MMPs and the activation of nuclear factor-kappa B (NF-κB) p65 and activator protein (AP)-1 were assessed by enzyme-linked immunosorbent assays. Results: LC and LIA inhibited the secretion of interleukin (IL)-6 and chemokine (C-C motif) ligand 5 in a concentration-dependent manner but did not affect the secretion of IL-8 by LPS-stimulated macrophages. LC and LIA also inhibited the secretion of MMP-7, -8, and -9 by macrophages. The suppression of cytokine and MMP secretion by LC and LIA was associated with the reduced activation of NF-κB p65 but not that of AP-1. Conclusion: The present study suggests that LC and LIA have potential for the development of novel host-modulating strategies for the treatment of cytokine and/or MMP-mediated disorders such as periodontitis. |
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Authors:
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Vu Dang La; Shin-Ichi Tanabe; Chantal Bergeron; Stefan Gafner; Daniel Grenier |
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Publication Detail:
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Type: Journal Article Date: 2010-08-19 |
Journal Detail:
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Title: Journal of periodontology Volume: 82 ISSN: 1943-3670 ISO Abbreviation: J. Periodontol. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-12-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8000345 Medline TA: J Periodontol Country: United States |
Other Details:
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Languages: eng Pagination: 122-8 Citation Subset: D; IM |
Affiliation:
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Research Group in Oral Ecology, Faculty of Dentistry, Laval University, Quebec City, QC. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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