| Modulation of mammalian cell processes by bacterial quorum sensing molecules. | |
| | |
MedLine Citation:
|
PMID: 21031309 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
Microbial pathogens use a wide repertoire of pathogen-associated molecular patterns (PAMPs) that affect host cell responses through activation of intracellular signaling events in a PAMP-specific manner. Here we describe a set of western blot-based methodologies for the evaluation of biochemical effects specifically induced by N-(3-oxo-acyl) homoserine lactones (3-oxo-AHLs) small molecules secreted by a number of Gram-negative bacteria, including the opportunistic human pathogen Pseudomonas aeruginosa. First, we will highlight the AHL-mediated effects on proapoptotic and stress pathways. Secondly, we will demonstrate that AHLs possess the ability to alter stimulus-induced NF-κB signaling, a key biochemical marker of inflammation and innate immune responses. |
| | |
Authors:
|
Vladimir V Kravchenko; Richard J Ulevitch; Gunnar F Kaufmann |
Related Documents
:
|
19369949 - Life on the inside: the intracellular lifestyle of cytosolic bacteria. 9624539 - Antibacterial agents--phagocytes: new concepts for old in immunomodulation. 21432289 - Mechanism of cytotoxicity of paraquat. 16406629 - Quorum sensing: dynamic response of pseudomonas aeruginosa to external signals. 20704879 - Intestinal bacteria and development of the antibody repertoire. 20133879 - The type iii effector hopf2pto targets arabidopsis rin4 protein to promote pseudomonas ... 15884439 - Influence of bacterial antigens on activation of human splenic dendritic cells. 20536569 - Effect of nkg2d ligand expression on host immune responses. 3030669 - Effects of lincomycin on the immune system. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
|
Title: Methods in molecular biology (Clifton, N.J.) Volume: 692 ISSN: 1940-6029 ISO Abbreviation: Methods Mol. Biol. Publication Date: 2011 |
Date Detail:
|
Created Date: 2010-10-29 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9214969 Medline TA: Methods Mol Biol Country: United States |
Other Details:
|
Languages: eng Pagination: 133-45 Citation Subset: IM |
Affiliation:
|
Department of Immunology & Microbial Science, The Scripps Research Institute, La Jolla, CA, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
| Grant Support | |
ID/Acronym/Agency:
|
AI079436/AI/NIAID NIH HHS; AI080715/AI/NIAID NIH HHS; R01 AI080715-03/AI/NIAID NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Luminescent reporters and their applications for the characterization of signals and signal-mimics t...
Next Document: Imaging N-acyl homoserine lactone quorum sensing in vivo.