Document Detail

Modulation of MOG 37-50-specific CD8+ T cell activation and expansion by CD43.
MedLine Citation:
PMID:  16890924     Owner:  NLM     Status:  MEDLINE    
Several recent reports have described an effector role for CD8(+) T cells during EAE. We have previously demonstrated reduced disease incidence and severity in CD43(-/-) mice following MOG immunization, and attributed this attenuation in disease progression to the effects of CD43 deficiency on CD4+ T cells. Here, we extend those studies to examine the effects of the loss of CD43 on MOG-specific CD8+ T cells. A reduced frequency of MOG-specific CD8+ T cells following immunization was observed in CD43(-/-) mice relative to wild-type controls, as demonstrated by intracellular cytokine and MHC tetramer staining. In addition, adoptive transfer of CD8+ MOG 35-55-primed LN cells from CD43(-/-) mice resulted in significantly attenuated EAE induction as compared to recipients of wild-type CD8+ MOG-primed cells. Analysis of intracellular signaling intermediates revealed a deficiency in the ability of MOG-specific CD8+ T cells to phosphorylate ERK in response to antigen. These results characterize an important role for CD43 during the activation and expansion of autoreactive MOG-specific CD8+ T cells.
Mandy L Ford; Brian D Evavold
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2006-08-07
Journal Detail:
Title:  Cellular immunology     Volume:  240     ISSN:  0008-8749     ISO Abbreviation:  Cell. Immunol.     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-08-29     Completed Date:  2006-10-04     Revised Date:  2011-08-23    
Medline Journal Info:
Nlm Unique ID:  1246405     Medline TA:  Cell Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  53-61     Citation Subset:  IM    
Department of Microbiology and Immunology, Emory University, Atlanta, GA 30322, USA.
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MeSH Terms
Adoptive Transfer
Antigens / immunology
Antigens, CD43 / immunology*
CD8-Positive T-Lymphocytes / cytology*,  immunology*
Cell Movement
Central Nervous System / immunology
Cross-Priming / immunology*
Encephalomyelitis, Autoimmune, Experimental / chemically induced
Extracellular Signal-Regulated MAP Kinases / metabolism
Lymph Nodes / cytology
Lymphocyte Activation*
Major Histocompatibility Complex / immunology
Myelin-Associated Glycoprotein / chemistry,  immunology*
Protein Structure, Quaternary
Spleen / cytology
Grant Support
Reg. No./Substance:
0/Antigens; 0/Antigens, CD43; 0/Myelin-Associated Glycoprotein; 0/myelin oligodendrocyte glycoprotein; EC Signal-Regulated MAP Kinases

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