| Modulation of MOG 37-50-specific CD8+ T cell activation and expansion by CD43. | |
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MedLine Citation:
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PMID: 16890924 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Several recent reports have described an effector role for CD8(+) T cells during EAE. We have previously demonstrated reduced disease incidence and severity in CD43(-/-) mice following MOG immunization, and attributed this attenuation in disease progression to the effects of CD43 deficiency on CD4+ T cells. Here, we extend those studies to examine the effects of the loss of CD43 on MOG-specific CD8+ T cells. A reduced frequency of MOG-specific CD8+ T cells following immunization was observed in CD43(-/-) mice relative to wild-type controls, as demonstrated by intracellular cytokine and MHC tetramer staining. In addition, adoptive transfer of CD8+ MOG 35-55-primed LN cells from CD43(-/-) mice resulted in significantly attenuated EAE induction as compared to recipients of wild-type CD8+ MOG-primed cells. Analysis of intracellular signaling intermediates revealed a deficiency in the ability of MOG-specific CD8+ T cells to phosphorylate ERK in response to antigen. These results characterize an important role for CD43 during the activation and expansion of autoreactive MOG-specific CD8+ T cells. |
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Authors:
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Mandy L Ford; Brian D Evavold |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2006-08-07 |
Journal Detail:
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Title: Cellular immunology Volume: 240 ISSN: 0008-8749 ISO Abbreviation: Cell. Immunol. Publication Date: 2006 Mar |
Date Detail:
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Created Date: 2006-08-29 Completed Date: 2006-10-04 Revised Date: 2011-08-23 |
Medline Journal Info:
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Nlm Unique ID: 1246405 Medline TA: Cell Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 53-61 Citation Subset: IM |
Affiliation:
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Department of Microbiology and Immunology, Emory University, Atlanta, GA 30322, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adoptive Transfer Animals Antigens / immunology Antigens, CD43 / immunology* CD8-Positive T-Lymphocytes / cytology*, immunology* Cell Movement Central Nervous System / immunology Cross-Priming / immunology* Encephalomyelitis, Autoimmune, Experimental / chemically induced Extracellular Signal-Regulated MAP Kinases / metabolism Female Lymph Nodes / cytology Lymphocyte Activation* Major Histocompatibility Complex / immunology Mice Myelin-Associated Glycoprotein / chemistry, immunology* Phosphorylation Protein Structure, Quaternary Spleen / cytology |
| Grant Support | |
ID/Acronym/Agency:
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AI056017/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antigens; 0/Antigens, CD43; 0/Myelin-Associated Glycoprotein; 0/myelin oligodendrocyte glycoprotein; EC 2.7.11.24/Extracellular Signal-Regulated MAP Kinases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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