Document Detail


Modulation of M1 and M2 muscarinic receptor subtypes following repeated organophosphate exposure in rats.
MedLine Citation:
PMID:  1440606     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Repeated exposure to organophosphates has been shown to cause a decrease in muscarinic cholinergic receptors in the central and peripheral nervous system. The present study measured the modulation of M1 and M2 muscarinic receptor subtypes in rat brain areas during and following a 2-week daily exposure to the organophosphate disulfoton. The radioligands [3H]telenzepine and [3H]AFDX 384 were utilized to label M1 and M2 receptors, respectively. The study found comparable down-regulation in both [3H]telenzepine- and [3H]AFDX 384-labeled receptors in cortex, hippocampus, and striatum during exposure. Recovery of M2 subtype was slower than recovery of M1, especially in the hippocampus. The results suggest that M1 and M2 receptor subtypes may be similarly regulated in response to subchronic exposure to organophosphates, but that recovery of receptor subtypes to control levels may be governed by distinct factors.
Authors:
B B Fitzgerald; L G Costa
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Toxicology and applied pharmacology     Volume:  117     ISSN:  0041-008X     ISO Abbreviation:  Toxicol. Appl. Pharmacol.     Publication Date:  1992 Nov 
Date Detail:
Created Date:  1992-12-15     Completed Date:  1992-12-15     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0416575     Medline TA:  Toxicol Appl Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  122-5     Citation Subset:  IM    
Affiliation:
Department of Environmental Health, University of Washington, Seattle 98195.
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain / metabolism,  ultrastructure
Disulfoton / toxicity*
Male
Organophosphorus Compounds / toxicity*
Parasympatholytics / metabolism,  pharmacology
Pirenzepine / analogs & derivatives,  metabolism,  pharmacology
Rats
Rats, Inbred Strains
Receptors, Muscarinic / drug effects*,  metabolism
Tritium
Grant Support
ID/Acronym/Agency:
ES-04696/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Organophosphorus Compounds; 0/Parasympatholytics; 0/Receptors, Muscarinic; 10028-17-8/Tritium; 102394-31-0/otenzepad; 118290-27-0/AFDX 384; 28797-61-7/Pirenzepine; 298-04-4/Disulfoton; 80880-90-6/telenzepine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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