| Modulation of leptin levels by oxidized linoleic acid: a connection to atherosclerosis? | |
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MedLine Citation:
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PMID: 21186986 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The objective of the study was to determine the effects of oxidized linoleic acid (Ox-LA) on plasma leptin and to determine the relationship between plasma leptin levels and atherosclerosis in animals treated with Ox-LA. Low-density lipoprotein (LDL) receptor knockout (LDL r(-/-)) mice were fed a high fat diet with or without Ox-LA for 11 weeks. Plasma leptin levels in the high fat group consuming Ox-LA were significantly higher (14,052 ± 601 pg/mL vs. 10,950 ± 541 pg/mL; P < .01) compared to the group receiving the high fat diet alone. There was a highly significant correlation between the plasma leptin levels and aortic atherosclerotic lesions. From this we conclude that chronic exposure to dietary Ox-LA increases the plasma levels of leptin in LDL r(-/-) mice on a high fat diet. Considering our previous finding that dietary Ox-LA increased atherosclerosis, the current findings emphasize the need to reduce dietary intake of oxidized fat. |
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Authors:
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Meera Penumetcha; Nadya Merchant; Sampath Parthasarathy |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-12-27 |
Journal Detail:
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Title: Journal of medicinal food Volume: 14 ISSN: 1557-7600 ISO Abbreviation: J Med Food Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-03-29 Completed Date: 2011-07-12 Revised Date: 2012-04-02 |
Medline Journal Info:
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Nlm Unique ID: 9812512 Medline TA: J Med Food Country: United States |
Other Details:
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Languages: eng Pagination: 441-3 Citation Subset: IM |
Affiliation:
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Division of Nutrition, School of Health Professions, Georgia State University, Atlanta, Georgia, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aorta / pathology Atherosclerosis / chemically induced*, pathology* Cholesterol, Dietary / administration & dosage Cholesterol, LDL / blood Leptin / blood* Linoleic Acid / administration & dosage* Lipid Peroxidation* Lipoproteins, LDL / blood Male Mice Mice, Knockout Obesity / pathology Oxidative Stress Receptors, LDL / metabolism Triglycerides / blood |
| Grant Support | |
ID/Acronym/Agency:
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HL52628-03/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, Dietary; 0/Cholesterol, LDL; 0/Leptin; 0/Lipoproteins, LDL; 0/Receptors, LDL; 0/Triglycerides; 2197-37-7/Linoleic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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