| Modulation of IFNAR1 mRNA expression in multiple sclerosis patients. | |
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MedLine Citation:
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PMID: 18482773 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Interferon-beta receptor (IFNAR) is composed of 2 subunits, IFNAR1 and IFNAR2, the latter of which is expressed as functional (IFNAR2.2), non-functional (IFNAR2.1) and soluble (IFNAR2.3) isoform. Real-Time PCR analysis of mRNA for all IFNAR components in multiple sclerosis patients naïve for therapy and undergoing long-term treatment with interferon-beta shows that IFNAR1 mRNA level is lower than in healthy controls. If long-term treated patients are divided according to the production of mRNA for Myxovirus protein-A, a marker of interferon-beta bioactivity, IFNAR1 mRNA reaches the values observed in controls only in Myxovirus protein-A-induced patients. Since chronic cell stimulation by interferon-beta induces IFNAR protein down-regulation, we suggest that the increase of IFNAR1 mRNA might serve as a mechanism for counterbalancing the loss of protein receptor, enhancing, at least in this sub-group of patients, cell responsiveness to interferon-beta. |
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Authors:
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Federico Serana; Alessandra Sottini; Claudia Ghidini; Cinzia Zanotti; Ruggero Capra; Cinzia Cordioli; Luigi Caimi; Luisa Imberti |
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Publication Detail:
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Type: Journal Article Date: 2008-05-15 |
Journal Detail:
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Title: Journal of neuroimmunology Volume: 197 ISSN: 0165-5728 ISO Abbreviation: J. Neuroimmunol. Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-06-10 Completed Date: 2008-09-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8109498 Medline TA: J Neuroimmunol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 54-62 Citation Subset: IM |
Affiliation:
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Laboratorio di Biotecnologie, Diagnostic Department, Spedali Civili di Brescia, p.le Spedali Civili 1, 25123, Brescia, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Female GTP-Binding Proteins / analysis, biosynthesis Humans Interferon-beta / therapeutic use Male Multiple Sclerosis, Chronic Progressive / immunology*, metabolism* Multiple Sclerosis, Relapsing-Remitting / drug therapy, immunology*, metabolism* Orthomyxoviridae / immunology Protein Isoforms / biosynthesis, genetics RNA, Messenger / biosynthesis* Receptor, Interferon alpha-beta / biosynthesis*, genetics*, physiology |
| Chemical | |
Reg. No./Substance:
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0/IFNAR1 protein, human; 0/IFNAR2 protein, human; 0/Protein Isoforms; 0/RNA, Messenger; 0/myxovirus resistance proteins; 156986-95-7/Receptor, Interferon alpha-beta; 77238-31-4/Interferon-beta; EC 3.6.1.-/GTP-Binding Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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