Document Detail

Modulation of host cell function by Legionella pneumophila type IV effectors.
MedLine Citation:
PMID:  20929312     Owner:  NLM     Status:  MEDLINE    
Macrophages and protozoa ingest bacteria by phagocytosis and destroy these microbes using a conserved pathway that mediates fusion of the phagosome with lysosomes. To survive within phagocytic host cells, bacterial pathogens have evolved a variety of strategies to avoid fusion with lysosomes. A virulence strategy used by the intracellular pathogen Legionella pneumophila is to manipulate host cellular processes using bacterial proteins that are delivered into the cytosolic compartment of the host cell by a specialized secretion system called Dot/Icm. The proteins delivered by the Dot/Icm system target host factors that play evolutionarily conserved roles in controlling membrane transport in eukaryotic cells, which enables L. pneumophila to create an endoplasmic reticulum-like vacuole that supports intracellular replication in both protozoan and mammalian host cells. This review focuses on intracellular trafficking of L. pneumophila and describes how bacterial proteins contribute to modulation of host processes required for survival within host cells.
Andree Hubber; Craig R Roy
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Annual review of cell and developmental biology     Volume:  26     ISSN:  1530-8995     ISO Abbreviation:  Annu. Rev. Cell Dev. Biol.     Publication Date:  2010  
Date Detail:
Created Date:  2010-10-08     Completed Date:  2010-10-26     Revised Date:  2012-12-07    
Medline Journal Info:
Nlm Unique ID:  9600627     Medline TA:  Annu Rev Cell Dev Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  261-83     Citation Subset:  IM    
Section of Microbial Pathogenesis, School of Medicine, Yale University, New Haven, Connecticut 06536, USA.
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MeSH Terms
Bacterial Proteins / metabolism
Legionella pneumophila / metabolism*,  pathogenicity*
Lysosomes / metabolism
Macrophages / cytology,  metabolism
Microbial Viability
Phagosomes / metabolism
Grant Support
R01 AI041699-15/AI/NIAID NIH HHS
Reg. No./Substance:
0/Bacterial Proteins

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