| Modulation of host cell function by Legionella pneumophila type IV effectors. | |
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MedLine Citation:
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PMID: 20929312 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Macrophages and protozoa ingest bacteria by phagocytosis and destroy these microbes using a conserved pathway that mediates fusion of the phagosome with lysosomes. To survive within phagocytic host cells, bacterial pathogens have evolved a variety of strategies to avoid fusion with lysosomes. A virulence strategy used by the intracellular pathogen Legionella pneumophila is to manipulate host cellular processes using bacterial proteins that are delivered into the cytosolic compartment of the host cell by a specialized secretion system called Dot/Icm. The proteins delivered by the Dot/Icm system target host factors that play evolutionarily conserved roles in controlling membrane transport in eukaryotic cells, which enables L. pneumophila to create an endoplasmic reticulum-like vacuole that supports intracellular replication in both protozoan and mammalian host cells. This review focuses on intracellular trafficking of L. pneumophila and describes how bacterial proteins contribute to modulation of host processes required for survival within host cells. |
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Authors:
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Andree Hubber; Craig R Roy |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Annual review of cell and developmental biology Volume: 26 ISSN: 1530-8995 ISO Abbreviation: Annu. Rev. Cell Dev. Biol. Publication Date: 2010 |
Date Detail:
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Created Date: 2010-10-08 Completed Date: 2010-10-26 Revised Date: 2012-12-07 |
Medline Journal Info:
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Nlm Unique ID: 9600627 Medline TA: Annu Rev Cell Dev Biol Country: United States |
Other Details:
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Languages: eng Pagination: 261-83 Citation Subset: IM |
Affiliation:
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Section of Microbial Pathogenesis, School of Medicine, Yale University, New Haven, Connecticut 06536, USA. andree.hubber@yale.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bacterial Proteins / metabolism Humans Legionella pneumophila / metabolism*, pathogenicity* Lysosomes / metabolism Macrophages / cytology, metabolism Microbial Viability Phagocytosis* Phagosomes / metabolism Virulence |
| Grant Support | |
ID/Acronym/Agency:
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R01 AI041699-15/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Bacterial Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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