| Modulation of G-protein linked cAMP accumulation in immortalized murine cortical astrocytes by retroviral infection. | |
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MedLine Citation:
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PMID: 10799689 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present study characterized beta-adrenergic receptors (beta-AR) in a clonal cell line (C1) immortalized from cerebral cortical astroglial cells of FVB/N mice. We also determined whether the wild type Moloney murine leukemia virus (wt-MoMuLV) and one of its neuropathogenic mutants, ts1-MoMuLV, modulated the beta-AR system in these cells. We observed that C1 cells possess a functional beta-AR system coupled to cAMP accumulation and capable of normal agonist-induced regulation (desensitization). Significant increases were observed in forskolin stimulated cAMP accumulation in C1 cells infected by wt MoMuLV and by ts1-MoMuLV. In contrast, the cAMP response to beta-AR stimulated by isoproterenol was relatively spared after viral exposure. |
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Authors:
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S Raofi; P K Wong; R E Wilcox |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Brain research Volume: 862 ISSN: 0006-8993 ISO Abbreviation: Brain Res. Publication Date: 2000 Apr |
Date Detail:
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Created Date: 2000-06-21 Completed Date: 2000-06-21 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0045503 Medline TA: Brain Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 230-3 Citation Subset: IM |
Affiliation:
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Division of Pharmacology and Toxicology, College of Pharmacy, University of Texas at Austin, Austin, TX, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenylate Cyclase
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metabolism Adrenergic beta-Agonists / pharmacology Adrenergic beta-Antagonists / pharmacology Animals Astrocytes / cytology, metabolism, virology* Biological Transport / drug effects, physiology Cell Line, Transformed / chemistry, enzymology, virology Cyclic AMP / metabolism* Forskolin / pharmacology GTP-Binding Proteins / metabolism* Isoproterenol / pharmacology Leukemia, Experimental / metabolism* Mice Moloney murine leukemia virus* Neocortex / cytology Propranolol / pharmacology Receptors, Adrenergic, beta / metabolism Retroviridae Infections / metabolism* Tumor Virus Infections / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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AI28283/AI/NIAID NIH HHS; CA45124/CA/NCI NIH HHS; MH57181/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Agonists; 0/Adrenergic beta-Antagonists; 0/Receptors, Adrenergic, beta; 525-66-6/Propranolol; 60-92-4/Cyclic AMP; 66428-89-5/Forskolin; 7683-59-2/Isoproterenol; EC 3.6.1.-/GTP-Binding Proteins; EC 4.6.1.1/Adenylate Cyclase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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