Document Detail

Modulation of G-protein linked cAMP accumulation in immortalized murine cortical astrocytes by retroviral infection.
MedLine Citation:
PMID:  10799689     Owner:  NLM     Status:  MEDLINE    
The present study characterized beta-adrenergic receptors (beta-AR) in a clonal cell line (C1) immortalized from cerebral cortical astroglial cells of FVB/N mice. We also determined whether the wild type Moloney murine leukemia virus (wt-MoMuLV) and one of its neuropathogenic mutants, ts1-MoMuLV, modulated the beta-AR system in these cells. We observed that C1 cells possess a functional beta-AR system coupled to cAMP accumulation and capable of normal agonist-induced regulation (desensitization). Significant increases were observed in forskolin stimulated cAMP accumulation in C1 cells infected by wt MoMuLV and by ts1-MoMuLV. In contrast, the cAMP response to beta-AR stimulated by isoproterenol was relatively spared after viral exposure.
S Raofi; P K Wong; R E Wilcox
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Brain research     Volume:  862     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  2000 Apr 
Date Detail:
Created Date:  2000-06-21     Completed Date:  2000-06-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  230-3     Citation Subset:  IM    
Division of Pharmacology and Toxicology, College of Pharmacy, University of Texas at Austin, Austin, TX, USA.
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MeSH Terms
Adenylate Cyclase / metabolism
Adrenergic beta-Agonists / pharmacology
Adrenergic beta-Antagonists / pharmacology
Astrocytes / cytology,  metabolism,  virology*
Biological Transport / drug effects,  physiology
Cell Line, Transformed / chemistry,  enzymology,  virology
Cyclic AMP / metabolism*
Forskolin / pharmacology
GTP-Binding Proteins / metabolism*
Isoproterenol / pharmacology
Leukemia, Experimental / metabolism*
Moloney murine leukemia virus*
Neocortex / cytology
Propranolol / pharmacology
Receptors, Adrenergic, beta / metabolism
Retroviridae Infections / metabolism*
Tumor Virus Infections / metabolism*
Grant Support
Reg. No./Substance:
0/Adrenergic beta-Agonists; 0/Adrenergic beta-Antagonists; 0/Receptors, Adrenergic, beta; 525-66-6/Propranolol; 60-92-4/Cyclic AMP; 66428-89-5/Forskolin; 7683-59-2/Isoproterenol; EC 3.6.1.-/GTP-Binding Proteins; EC Cyclase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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