| Modulation of Cytokine and Chemokine Secretions in Rhesus Monkey Trophoblast Co-Culture With Decidual but not Peripheral Blood Monocyte-Derived Macrophages. | |
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MedLine Citation:
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PMID: 21276119 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Citation Rozner AE, Dambaeva SV, Drenzek JG, Durning M, Golos TG. Modulation of cytokine and chemokine secretions in rhesus monkey trophoblast co-culture with decidual but not peripheral blood monocyte-derived macrophages. Am J Reprod Immunol 2011 Problem Decidual macrophages are thought to promote pregnancy success, in part through interactions with invading trophoblast cells in hemochorial placentation. However, the factors that constitute this regulatory cross talk are not well understood. Method of study Rhesus monkey decidual and peripheral blood-derived macrophages were co-cultured with primary Rhesus trophoblasts. Macrophage functions including cell-surface marker expression, antigen uptake and processing, in vitro migration, and cytokine and chemokine secretions were evaluated. Results While most macrophage functions were unchanged by trophoblast co-culture, changes in the secretion of selected cytokines and the migration of trophoblasts were noted when decidual (but generally, not peripheral blood monocyte-derived) macrophages were cultured with trophoblasts. In addition, basal secretion differed significantly between peripheral blood-derived and decidual macrophages for a broad spectrum of cytokines. When trophoblasts were pre-treated with an anti-Mamu-AG antibody, 25D3, there was no change in cytokine or chemokine secretion. Conclusion Macrophage cytokine expression can be modulated by trophoblast co-culture, but it remains unclear how Mamu-AG is involved. |
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Authors:
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Ann E Rozner; Svetlana V Dambaeva; Jessica G Drenzek; Maureen Durning; Thaddeus G Golos |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-1-31 |
Journal Detail:
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Title: American journal of reproductive immunology (New York, N.Y. : 1989) Volume: - ISSN: 1600-0897 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-1-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8912860 Medline TA: Am J Reprod Immunol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 John Wiley & Sons A/S. |
Affiliation:
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Department of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI, USA School of Veterinary Medicine, Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, WI, USA School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA The Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI, USA. |
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