Document Detail

Modulation of C(16:0) -ceramide in hypertrophied immature hearts by losartan.
MedLine Citation:
PMID:  23316794     Owner:  NLM     Status:  Publisher    
BACKGROUND: The angiotensin type 2 (AT2)-receptor plays a unique role on growth inhibition in adult myocardium via modulation of ceramide synthesis. Angiotensin type 1 (AT1)-receptor blockade results in increased AT2-receptor activation by angiotensin II, and AT1-receptor blockers are sometimes prescribed to children for the treatment of cardiac hypertrophy or heart failure. We investigated the changes of ceramide lipid components in hypertrophied immature rabbit hearts after chronic administration of the AT1-receptor blocker, losartan. METHODS AND RESULTS: One-week-old Japanese white rabbits were randomly divided into three groups: sham operated control rabbits (Group S), rabbits given distilled water orally for 21 days after aortic constriction (Group H), and rabbits given losartan orally for 21 days after aortic constriction (Group H+L). Compared with Group S, the hypertrophy index and left ventricular posterior wall thickness were significantly increased in Group H, but were not different in Group H+L. Total myocardial ceramide levels in Group H and Group H+L were suppressed compared with Group S. The relative fatty acid components of myocardial ceramide in Group H were the same as that in Group S, but Group H+L showed a significant increase of the C16:0 component. CONCLUSIONS: The total cardiac ceramide levels are depressed by pressure overload of immature rabbit hearts. Losartan reduced the hypertrophy with selective increase of the relative amount of C16:0-ceramide.
Toshiyuki Itoi; Tatsujiro Oka; Naoto Terada
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-14
Journal Detail:
Title:  Pediatrics international : official journal of the Japan Pediatric Society     Volume:  -     ISSN:  1442-200X     ISO Abbreviation:  Pediatr Int     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100886002     Medline TA:  Pediatr Int     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2013 The Authors. Pediatrics International © 2013 Japan Pediatric Society.
Department of Pediatric Cardiology and Nephrology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine.
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