| Modulation of the BP response to diet by genes in the renin-angiotensin system and the adrenergic nervous system. | |
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MedLine Citation:
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PMID: 21088669 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Essential hypertension results from the interaction of several genetic and environmental factors. Identification of genetic factors that modulate blood pressure (BP) response to interventions can lead to improved strategies for prevention and control. The purpose of this study was to identify genes that modulate BP response to dietary interventions. METHODS: We used data and samples collected in two randomized feeding studies to determine the extent to which genetic architecture is associated with the effect on BP of sodium intake and the Dietary Approaches to Stop Hypertension (DASH) dietary pattern. Participants in both trials were adults with above-optimal BP or unmedicated stage 1 hypertension. Genomic DNA was typed for several candidate genes. RESULTS: The effect of sodium intake on BP differed by genotype at the angiotensinogen, β2-adrenergic receptor, and kallikrein loci. The effect of DASH dietary pattern on BP differed by genotype at the β2-adrenergic receptor locus. CONCLUSIONS: These findings have implications for understanding the mechanism(s) through which diet affects BP, the heterogeneity of these effects, and the extent to which dietary interventions can modulate genetic predisposition. |
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Authors:
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Laura P Svetkey; Emily L Harris; Eden Martin; William M Vollmer; Gayle T Meltesen; Vincent Ricchiuti; Gordon Williams; Lawrence J Appel; George A Bray; Thomas J Moore; Michelle P Winn; Paul R Conlin |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural Date: 2010-11-18 |
Journal Detail:
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Title: American journal of hypertension Volume: 24 ISSN: 1941-7225 ISO Abbreviation: Am. J. Hypertens. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-20 Completed Date: 2011-05-03 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 8803676 Medline TA: Am J Hypertens Country: United States |
Other Details:
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Languages: eng Pagination: 209-17 Citation Subset: IM |
Affiliation:
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Duke University Medical Center, Durham, North Carolina, USA. svetk001@mc.duke.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic Fibers
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metabolism* Adult Angiotensinogen / genetics Blood Pressure / genetics* Diet, Sodium-Restricted* Female Genetic Association Studies Genetic Predisposition to Disease Humans Hypertension / diet therapy*, genetics*, metabolism, physiopathology Kallikreins / genetics Linkage Disequilibrium Male Middle Aged Phenotype Polymorphism, Single Nucleotide Receptors, Adrenergic, beta-2 / genetics Renin-Angiotensin System / genetics* Risk Assessment Risk Factors Sodium, Dietary / adverse effects* Sympathetic Nervous System / metabolism*, physiopathology Treatment Outcome |
| Grant Support | |
ID/Acronym/Agency:
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K24 DK63214/DK/NIDDK NIH HHS; R01 DK074748-06/DK/NIDDK NIH HHS; R01 HL057114-07/HL/NHLBI NIH HHS; R01 HL77234/HL/NHLBI NIH HHS; R01HL57114/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/ADRB2 protein, human; 0/Receptors, Adrenergic, beta-2; 0/Sodium, Dietary; 11002-13-4/Angiotensinogen; EC 3.4.21.-/Kallikreins |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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