| Modulating thrombotic potential in catheter-based percutaneous coronary and peripheral vascular interventions. | |
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MedLine Citation:
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PMID: 15277783 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Thrombosis is an obligatory consequence of all percutaneous vascular interventions. Balloon angioplasty, intravascular stents and other devices routinely used to facilitate dilatation of critical vascular stenoses result in fracture of the intima and exposure of the thrombogenic subendothelium with initiation and perpetuation of platelet activation and aggregation. This not uncommonly results in thrombus formation that may lead to abrupt vessel closure, distal ischemia and tissue infarction, and target organ dysfunction. Fortunately, advances in our understanding of the mechanisms that underlie vascular thrombosis have led to advances in the use of adjunctive pharmacological agents that modulate this pathophysiological response and have led to important reductions in the incidence and severity of thrombotic complications of percutaneous transluminal interventions. |
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Authors:
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James L Orford; Peter B Berger |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of thrombosis and thrombolysis Volume: 17 ISSN: 0929-5305 ISO Abbreviation: J. Thromb. Thrombolysis Publication Date: 2004 Feb |
Date Detail:
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Created Date: 2004-07-27 Completed Date: 2005-02-08 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 9502018 Medline TA: J Thromb Thrombolysis Country: Netherlands |
Other Details:
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Languages: eng Pagination: 11-20 Citation Subset: IM |
Affiliation:
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Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angioplasty, Balloon
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adverse effects* Angioplasty, Transluminal, Percutaneous Coronary / adverse effects* Humans Severity of Illness Index Thrombosis / drug therapy*, epidemiology, physiopathology*, prevention & control Vascular Diseases / drug therapy, physiopathology, surgery |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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