| Modulating impact of human chorionic gonadotropin hormone on the maturation and function of hematopoietic cells. | |
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MedLine Citation:
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PMID: 21878542 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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hCG hormone is a naturally occurring, immune-modulating agent, which is highly expressed during pregnancy and causes improvements of some autoimmune diseases such as multiple sclerosis and Crohn's disease. Little is known about its immune-modulating effects. This study in MNCs of women who received hCG as preconditioning prior to IVF demonstrates that hCG increases anti-inflammatory IL-27 expression and reduces inflammatory IL-17 expression. In addition, we found increased IL-10 levels and elevated numbers of Tregs in peripheral blood of women after hCG application. Rejection of allogeneic skin grafts was delayed in female mice receiving hCG. We conclude that hCG may be useful for the induction of immune tolerance in solid organ transplantation. |
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Authors:
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Michael Koldehoff; Thomas Katzorke; Natalie C Wisbrun; Dirk Propping; Susanne Wohlers; Peter Bielfeld; Nina K Steckel; Dietrich W Beelen; Ahmet H Elmaagacli |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-30 |
Journal Detail:
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Title: Journal of leukocyte biology Volume: - ISSN: 1938-3673 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-8-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8405628 Medline TA: J Leukoc Biol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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*Department of Bone Marrow Transplantation, West German Cancer Center, Medical School of University of Duisburg-Essen, and. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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