| Modifying the temporal profile of the high-potency sweetener neotame. | |
| | |
MedLine Citation:
|
PMID: 11262029 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
It is possible, using hydrophobic organic acids (such as cinnamate) or hydroxyamino acids (such as serine and tyrosine), to modify the temporal profile of the high-potency sweetener neotame. On the basis of Monte Carlo simulations, it was concluded that it is unlikely that this effect is due to direct interaction between the neotame molecule and the taste modifier. It is shown, using conformational analysis and molecular modeling, that the taste modifiers can adopt low-energy conformers which mimic the proposed active conformation of neotame, which suggests that the modifiers may compete for binding at the receptor site. |
| | |
Authors:
|
I Prakash; I E Bishay; N Desai; D E Walters |
Related Documents
:
|
15347259 - In situ hybridization: detecting viral nucleic acid in formalin-fixed, paraffin-embedde... 17219019 - Biological polyamines inhibit nucleic-acid-induced polymerisation of prion protein. 21337839 - The relationship between acid-suppressing drugs and phytobezoar formation: a retrospect... 828199 - Search for scrapie-specific rna and attempts to detect an infectious dna or rna. 18409029 - Nucleic acids bind to nanoparticulate iron (ii) monosulphide in aqueous solutions. 21298479 - Intragastrically administered lysophosphatidic acids protect against gastric ulcer in r... 14694189 - Specificity determinants and diversification of the brassica self-incompatibility polle... 16597279 - The effect of microwave heating on the acidity of 0.9% saline in 1 litre and 100 ml pol... 6593319 - Fbj virus-induced osteosarcoma contains type i, type i trimer, type iii as well as type... |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
|
Title: Journal of agricultural and food chemistry Volume: 49 ISSN: 0021-8561 ISO Abbreviation: J. Agric. Food Chem. Publication Date: 2001 Feb |
Date Detail:
|
Created Date: 2001-03-23 Completed Date: 2001-05-24 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0374755 Medline TA: J Agric Food Chem Country: United States |
Other Details:
|
Languages: eng Pagination: 786-9 Citation Subset: IM |
Affiliation:
|
The NutraSweet Company, 699 Wheeling Road, Mount Prospect, Illinois 60056, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Cinnamates Dipeptides / chemistry* Drug Stability Models, Molecular Molecular Conformation Monte Carlo Method Serine Sweetening Agents / chemistry* Taste* Tyrosine |
| Chemical | |
Reg. No./Substance:
|
0/Cinnamates; 0/Dipeptides; 0/Sweetening Agents; 0/neotame; 55520-40-6/Tyrosine; 56-45-1/Serine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Stability of monoterpenes encapsulated in gum Arabic by spray-drying.
Next Document: Aroma extract dilution analysis of a beeflike process flavor from extruded enzyme-hydrolyzed soybean...