Document Detail

Modifying the n-6/n-3 polyunsaturated fatty acid ratio of a high-saturated fat challenge does not acutely attenuate postprandial changes in inflammatory markers in men with metabolic syndrome.
MedLine Citation:
PMID:  19625064     Owner:  NLM     Status:  MEDLINE    
Metabolic syndrome (MetS) features chronic inflammation and exaggerated postprandial triacylglyceride (TAG) responses. Fasting concentrations of interleukin-6 (IL-6) and C-reactive protein (CRP), key inflammatory mediators, decrease after sustained n-3 polyunsaturated fatty acid (PUFA) intake; however, the ability of n-3 PUFA to attenuate postprandial inflammatory responses is not well studied. Thus, we examined the acute effect of modifying the n-6/n-3 PUFA ratio of a high-saturated fatty acid (SFA) oral fat tolerance test (OFTT) on postprandial TAG and inflammatory responses in men with MetS. Men (n = 8, > or = 45 years old) with MetS ingested 2 high-SFA OFTTs (1 g fat per kilogram body weight), with either a 20:1 (low n-3) or 2:1 (high n-3) n-6/n-3 PUFA ratio, and a water control in a randomized crossover design. Blood samples were collected for 8 hours after treatment to measure postprandial TAG, free fatty acids, IL-6, soluble IL-6 receptor, and CRP. Postprandial TAG increased at the same rate after ingestion of the low-n-3 and high-n-3 OFTTs; however, both OFTTs were significantly different from the water control. There were no differences in the rate at which IL-6 concentrations increased after ingestion of either of the OFTTs compared with water. Furthermore, neither time nor treatment affected circulating soluble IL-6 receptor or CRP concentrations. Thus, increasing the n-3 PUFA content of a high-SFA OFTT does not acutely change postprandial TAG or inflammatory responses in men with MetS.
Hilary M F Tulk; Lindsay E Robinson
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2009-07-21
Journal Detail:
Title:  Metabolism: clinical and experimental     Volume:  58     ISSN:  1532-8600     ISO Abbreviation:  Metab. Clin. Exp.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-11-16     Completed Date:  2009-11-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375267     Medline TA:  Metabolism     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1709-16     Citation Subset:  IM    
Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1.
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MeSH Terms
Biological Markers
C-Reactive Protein / metabolism
Cross-Over Studies
Fatty Acids / diagnostic use*
Fatty Acids, Nonesterified / blood
Fatty Acids, Omega-3 / blood*
Fatty Acids, Omega-6 / blood*
Glycerides / blood
Inflammation / blood*
Interleukin-6 / blood
Metabolic Syndrome X / blood*
Middle Aged
Postprandial Period / physiology*
Receptors, Interleukin-6 / metabolism
Reg. No./Substance:
0/Biological Markers; 0/Fatty Acids; 0/Fatty Acids, Nonesterified; 0/Fatty Acids, Omega-3; 0/Fatty Acids, Omega-6; 0/Glycerides; 0/Interleukin-6; 0/Receptors, Interleukin-6; 9007-41-4/C-Reactive Protein

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