Document Detail

Modifying effects of the naturally occurring antioxidants gamma-oryzanol, phytic acid, tannic acid and n-tritriacontane-16, 18-dione in a rat wide-spectrum organ carcinogenesis model.
MedLine Citation:
PMID:  1657429     Owner:  NLM     Status:  MEDLINE    
The modifying effects of the naturally occurring antioxidants gamma-oryzanol, phytic acid, tannic acid and n-tritriacontane-16, 18-dione (TTAD) were investigated in a rat wide-spectrum organ carcinogenesis model. Animals were initiated with two i.p. injections of 1000 mg/kg body wt 2,2'-dihydroxy-di-n-propylnitrosamine (DHPN) followed by two i.g. administrations of 1500 mg/kg body wt N-ethyl-N-hydroxy-ethylnitrosamine (EHEN), and then three s.c. injections of 75 mg/kg body wt 3,2'-dimethyl-4-aminobiphenyl (DMAB) during the first 3 weeks. Starting 1 week after the last injection, groups of rats received diet containing 1% gamma-oryzanol, 2% phytic acid, 0.2% TTAD or 1% tannic acid or basal diet alone for 32 weeks. Animals were then killed and complete autopsy was performed at the end of week 36. Histological examination revealed enhancement of lung carcinogenesis by gamma-oryzanol, and the incidence of urinary bladder papillomas to be increased by phytic acid. On the other hand, TTAD inhibited hepatic and pancreatic carcinogenesis. Phytic acid and tannic acid were marginally effective in inhibiting hepatic and colon carcinogenesis respectively. The results thus indicated that naturally occurring antioxidants each exert specific modifying effects depending on the organ site and indicate that wide-spectrum carcinogenesis models are useful for defining complex influences.
M Hirose; K Ozaki; K Takaba; S Fukushima; T Shirai; N Ito
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Carcinogenesis     Volume:  12     ISSN:  0143-3334     ISO Abbreviation:  Carcinogenesis     Publication Date:  1991 Oct 
Date Detail:
Created Date:  1991-11-25     Completed Date:  1991-11-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8008055     Medline TA:  Carcinogenesis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1917-21     Citation Subset:  IM    
First Department of Pathology, Nagoya City University Medical School, Japan.
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MeSH Terms
Adenoma / chemically induced,  prevention & control
Aminobiphenyl Compounds
Antilipemic Agents / adverse effects,  therapeutic use*
Body Weight / drug effects
Carcinogenicity Tests
Carcinoma, Hepatocellular / chemically induced,  prevention & control
Hydrolyzable Tannins / therapeutic use*
Kidney / anatomy & histology,  pathology
Liver / anatomy & histology,  pathology
Liver Neoplasms, Experimental / chemically induced,  prevention & control
Lung Neoplasms / chemically induced,  prevention & control
Neoplasms, Experimental / chemically induced,  prevention & control*
Organ Size / drug effects
Pancreatic Neoplasms / chemically induced,  prevention & control
Papilloma / chemically induced,  prevention & control
Paraffin / adverse effects,  therapeutic use*
Phenylpropionates / therapeutic use*
Phytic Acid / therapeutic use*
Rats, Inbred F344
Urinary Bladder Neoplasms / chemically induced,  prevention & control
Reg. No./Substance:
0/Aminobiphenyl Compounds; 0/Antilipemic Agents; 0/Hydrolyzable Tannins; 0/Phenylpropionates; 11042-64-1/gamma-oryzanol; 13394-86-0/2',3-dimethyl-4-aminobiphenyl; 24514-86-1/n-tritriacontane-16,18-dione; 8002-74-2/Paraffin; 83-86-3/Phytic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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