Document Detail

Modifying the dialysis prescription to reduce intradialytic hypotension.
MedLine Citation:
PMID:  11602457     Owner:  NLM     Status:  MEDLINE    
The dialysis prescription can have a substantial impact on the frequency of intradialytic hypotension (IDH). Plasma volume will decline to a greater extent when the ultrafiltration (UF) rate is rapid (high interdialytic weight gains and/or short treatment time), favoring IDH. The relationship of the target weight to the euvolemic weight determines the size of the interstitial fluid compartment, which is a major determinant of the rate of plasma refilling during UF. The higher the dialysate sodium, the smaller the decline in plasma volume for any given amount of UF. Use of a dialysate temperature that prevents a positive thermal balance during dialysis will allow peripheral vascular resistance to be maintained and minimize IDH. A higher ionized calcium during treatment facilitates an increase in cardiac output, a benefit that may be particularly notable in patients with depressed cardiac ejection fraction. Low dialysate magnesium, potassium, and bicarbonate may all favor IDH, although insufficient data are available for definitive conclusions. The choice of antihypertensive medication and the treatment schedule must be carefully considered in patients with IDH. The future integration of technology to monitor blood pressure, plasma volume, and thermal and sodium balance into a computer-based biofeedback system will very likely go a long way toward reducing the frequency of IDH.
R A Sherman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of kidney diseases : the official journal of the National Kidney Foundation     Volume:  38     ISSN:  1523-6838     ISO Abbreviation:  Am. J. Kidney Dis.     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2001-10-16     Completed Date:  2001-10-25     Revised Date:  2006-04-17    
Medline Journal Info:
Nlm Unique ID:  8110075     Medline TA:  Am J Kidney Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S18-25     Citation Subset:  IM    
UMDNJ-Robert Wood Johnson Medical School, Department of Medicine, Division of Nephrology, New Brunswick, NJ 08903-0019, USA.
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MeSH Terms
Antihypertensive Agents / administration & dosage
Bicarbonates / pharmacology
Blood Pressure / drug effects
Body Temperature
Body Water / physiology
Body Weight
Calcium / pharmacology
Dialysis Solutions / chemistry
Extracellular Space / physiology
Hemodiafiltration / methods
Hypotension / etiology,  physiopathology*
Magnesium / pharmacology
Membranes, Artificial
Plasma Volume / physiology
Potassium / pharmacology
Renal Dialysis / adverse effects*,  methods
Sodium / blood,  pharmacology
Vascular Resistance
Reg. No./Substance:
0/Antihypertensive Agents; 0/Bicarbonates; 0/Dialysis Solutions; 0/Membranes, Artificial; 7439-95-4/Magnesium; 7440-09-7/Potassium; 7440-23-5/Sodium; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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