Document Detail


Modifying calf lung surfactant by hexadecanol.
MedLine Citation:
PMID:  15667185     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Monolayer properties such as phase behavior, collapse pressure, and surface viscosity are determined by monolayer composition. Learning how to control these properties through simple additives is important to understanding lung surfactant monolayers and to designing optimal replacement surfactants for treatment of disease. The properties of Infasurf, a replacement lung surfactant derived from calf lung lavage organic extract, can be modified in a controlled fashion by adding hexadecanol (HD). Grazing incidence X-ray diffraction shows that the HD preferentially interacts with dipalmitoylphosphatidylcholine (DPPC), the main phospholipid component of Infasurf, in the same way as in binary mixtures of DPPC and HD. HD intercalates between the DPPC chains, which leads to a tighter packing of the two-dimensional lattice and greater stability of the solid phase. This molecular reorganization triggers changes at the macroscopic scale, leading to a greatly increased solid-phase fraction at a given surface pressure and order of magnitude increases in the surface shear viscosity. However, the collapse pressure decreases, and, hence, the minimum surface tension of the film increases.
Authors:
Coralie Alonso; Frank Bringezu; Gerald Brezesinski; Alan J Waring; Joseph A Zasadzinski
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Langmuir : the ACS journal of surfaces and colloids     Volume:  21     ISSN:  0743-7463     ISO Abbreviation:  Langmuir     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-01-25     Completed Date:  2006-05-25     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9882736     Medline TA:  Langmuir     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1028-35     Citation Subset:  IM    
Affiliation:
Departments of Chemical Engineering and Materials, University of California, Santa Barbara, CA 93106-5080, USA.
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MeSH Terms
Descriptor/Qualifier:
1,2-Dipalmitoylphosphatidylcholine / chemistry
Animals
Biological Products / chemistry
Cattle
Fatty Alcohols
Pulmonary Surfactants / chemistry*
Surface Properties
X-Ray Diffraction
Grant Support
ID/Acronym/Agency:
HL 51177/HL/NHLBI NIH HHS; HL 55534/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Biological Products; 0/Fatty Alcohols; 0/Pulmonary Surfactants; 0/calfactant; 2644-64-6/1,2-Dipalmitoylphosphatidylcholine; 36653-82-4/cetyl alcohol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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