| Modifier-concept of colorectal carcinogenesis: lipidomics as a technical tool in pathway analysis. | |
| | |
MedLine Citation:
|
PMID: 20397257 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In the modifier concept of intestinal carcinogenesis, lipids have been established as important variables and one focus is given to long-chain fatty acids. Increased consumption of long-chain fatty acids is in discussion to modify the development of colorectal carcinoma in humans. Saturated long-chain fatty acids, in particular, are assumed to promote carcinogenesis, whereas polyunsaturated forms are likely to act in the opposite way. At present, the molecular mechanisms behind these effects are not well understood. Recently, it has been demonstrated by lipidomics and associated molecular techniques, that activation and metabolic channeling of long-chain fatty acids are important mechanisms to modify colorectal carcinogenesis. In this Editorial, an overview about the present concept of long-chain fatty acids and its derivatives in colorectal carcinogenesis as well as technical algorithms in lipid analysis is given. |
| | |
Authors:
|
Nikolaus Gassler; Christina Klaus; Elke Kaemmerer; Andrea Reinartz |
Related Documents
:
|
10446297 - Solid-state nmr and ftir studies on bilayer membranes from 1,2- dioctadec-(14-ynoyl)-sn... 17242037 - Antimicrobial activity of long-chain, water-soluble, dendritic tricarboxylato amphiphiles. 2206707 - Separation and enrichment of alkylated globin chains as a means of improving the sensit... 17439117 - Molecular analysis of the benastatin biosynthetic pathway and genetic engineering of al... 12940747 - Mechanistic study of an improbable reaction: alkene dehydrogenation by the delta12 acet... 15065847 - Structural dynamics and processing of nucleic acids revealed by single-molecule spectro... |
Publication Detail:
|
Type: Editorial |
Journal Detail:
|
Title: World journal of gastroenterology : WJG Volume: 16 ISSN: 1007-9327 ISO Abbreviation: World J. Gastroenterol. Publication Date: 2010 Apr |
Date Detail:
|
Created Date: 2010-04-16 Completed Date: 2010-07-29 Revised Date: 2010-09-30 |
Medline Journal Info:
|
Nlm Unique ID: 100883448 Medline TA: World J Gastroenterol Country: China |
Other Details:
|
Languages: eng Pagination: 1820-7 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acyl Coenzyme A
/
metabolism Apoptosis Carcinogens Colorectal Neoplasms / metabolism* Dietary Fats Disease Progression Fatty Acids / metabolism Humans Lipids / chemistry* Models, Biological Proteomics / methods |
| Chemical | |
Reg. No./Substance:
|
0/Acyl Coenzyme A; 0/Carcinogens; 0/Dietary Fats; 0/Fatty Acids; 0/Lipids |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Role of monocytes and macrophages in experimental and human acute liver failure.
Next Document: Risk factors in familial forms of celiac disease.