| Modified vaccinia Ankara expressing HIVA antigen stimulates HIV-1-specific CD8 T cells in ELISpot assays of HIV-1 exposed infants. | |
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MedLine Citation:
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PMID: 16043269 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recombinant modified vaccinia virus Ankara expressing HIV-1 antigens (MVA.HIVA) was used in ELISpot assays to monitor HIV-1-specific T cell responses in infants. Responses to MVA.HIVA and HIV-1 peptides were examined in 13 infected and 81 exposed uninfected infants in Nairobi, Kenya. Responses to MVA.HIVA (38%) and peptide stimulation (38%) were similar in frequency (p=1.0) and magnitude (mean 176 versus 385 HIVSFU/10(6), p=0.96) in HIV-1 infected infants. In exposed uninfected infants, MVA.HIVA detected more positive responses and higher magnitude responses as compared to peptide. MVA.HIVA ELISpot is a sensitive method for quantification of HIV-1-specific CD8+ T cell responses in HIV-1 exposed infants. These results demonstrate the relevance of HIV-1 clade A consensus-derived immunogen HIVA for the viruses currently circulating in Nairobi. |
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Authors:
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Jennifer A Slyker; Barbara L Lohman; Dorothy A Mbori-Ngacha; Marie Reilly; Edmund G-T Wee; Tao Dong; Andrew J McMichael; Sarah L Rowland-Jones; Tomas Hanke; Grace John-Stewart |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S. Date: 2005-02-19 |
Journal Detail:
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Title: Vaccine Volume: 23 ISSN: 0264-410X ISO Abbreviation: Vaccine Publication Date: 2005 Sep |
Date Detail:
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Created Date: 2005-08-15 Completed Date: 2005-10-27 Revised Date: 2013-03-26 |
Medline Journal Info:
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Nlm Unique ID: 8406899 Medline TA: Vaccine Country: Netherlands |
Other Details:
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Languages: eng Pagination: 4711-9 Citation Subset: IM |
Affiliation:
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Department of Medical Microbiology, University of Nairobi, Kenya. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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CD8-Positive T-Lymphocytes
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immunology* Enzyme-Linked Immunosorbent Assay HIV Antigens / genetics, immunology* HIV Infections / immunology*, prevention & control HIV-1 / chemistry, classification, immunology* Humans Infant Lymphocyte Activation / immunology* Vaccination Vaccinia virus / genetics, immunology Viral Vaccines / genetics, immunology |
| Grant Support | |
ID/Acronym/Agency:
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D43 TW000007/TW/FIC NIH HHS; D43-TW00007/TW/FIC NIH HHS; HD 23412/HD/NICHD NIH HHS; K01 AI087369/AI/NIAID NIH HHS; P30 AI027757-12/AI/NIAID NIH HHS; R01 HD023412/HD/NICHD NIH HHS; R01 HD023412-19/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/HIV Antigens; 0/Viral Vaccines |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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