Document Detail

Modified snake venom in amyotrophic lateral sclerosis. Lack of clinical effectiveness.
MedLine Citation:
PMID:  7362484     Owner:  NLM     Status:  MEDLINE    
Diverse observations including neurological examination, manual muscle testing, quantitative electromyography, videotape esophagrams, and pulmonary function tests were used in a double-blind study evaluating the use of detoxified snake venoms as modified neurotoxin in 64 patients with amyotrophic lateral sclerosis (ALS) treated for six months. Transient periods of improvement were more common in the patients who received placebo. This study did not demonstrate any benefit from administration of modified snake venom to patients with ALS.
V M Rivera; M Grabois; W Deaton; W Breitbach; M Hines
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of neurology     Volume:  37     ISSN:  0003-9942     ISO Abbreviation:  Arch. Neurol.     Publication Date:  1980 Apr 
Date Detail:
Created Date:  1980-05-23     Completed Date:  1980-05-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372436     Medline TA:  Arch Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  201-3     Citation Subset:  AIM; IM    
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MeSH Terms
Amyotrophic Lateral Sclerosis / drug therapy*
Double-Blind Method
Forced Expiratory Volume
Middle Aged
Neurotoxins / therapeutic use*
Snake Venoms / therapeutic use*
Vital Capacity
Reg. No./Substance:
0/Neurotoxins; 0/Snake Venoms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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