Document Detail


Modified prosthetic vascular conduits.
MedLine Citation:
PMID:  18391121     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Atherosclerosis in the form of peripheral arterial disease results in significant morbidity. Surgical treatment options for peripheral arterial disease include angioplasty, endarterectomy, and bypass grafting. For bypass grafting, vein remains the conduit of choice; however, poor quality and limited availability have led to the use of prosthetic materials. Unfortunately, because of a lack of endothelium and compliance mismatch, neointimal hyperplasia develops aggressively, resulting in high failure rates. To improve graft patency, investigators have developed surgical, chemical, and biological graft modifications. This review describes common prosthetic materials, as well as approaches currently in use and under investigation to modify and improve prosthetic conduits for bypass grafting in an effort to improve graft patency rates.
Authors:
Muneera R Kapadia; Daniel A Popowich; Melina R Kibbe
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Circulation     Volume:  117     ISSN:  1524-4539     ISO Abbreviation:  Circulation     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-04-08     Completed Date:  2008-04-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1873-82     Citation Subset:  AIM; IM    
Affiliation:
Northwestern University Feinberg School of Medicine, Division of Vascular Surgery, Chicago, IL 60611, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anticoagulants / administration & dosage
Biocompatible Materials
Blood Vessel Prosthesis* / trends
Blood Vessel Prosthesis Implantation
Clinical Trials as Topic / statistics & numerical data
Coated Materials, Biocompatible
Drug Implants
Endothelial Cells / transplantation
Equipment Design
Equipment Failure
Graft Occlusion, Vascular / epidemiology,  prevention & control
Humans
Nitric Oxide Donors / administration & dosage
Polytetrafluoroethylene
Polyurethanes
Postoperative Complications / epidemiology,  etiology
Retrospective Studies
Transplantation, Autologous
Chemical
Reg. No./Substance:
0/Anticoagulants; 0/Biocompatible Materials; 0/Coated Materials, Biocompatible; 0/Drug Implants; 0/Nitric Oxide Donors; 0/Polyurethanes; 0/thoralon; 9002-84-0/Polytetrafluoroethylene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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