Document Detail

Modified paclitaxel-loaded nanoparticles for inhibition of hyperplasia in a rabbit arterial balloon injury model.
MedLine Citation:
PMID:  17372684     Owner:  NLM     Status:  MEDLINE    
PURPOSE: This study tested the possibility of localized intravascular infusion of positive charged paclitaxel-loaded nanoparticles (NPs) to better prevent neointimal formation in a rabbit carotid artery injury model. MATERIALS AND METHODS: NPs were prepared by oil-water emulsion/solvent evaporation technique using biodegradable poly (lactide-co-glycolide) (PLGA). A cationic surfactant, didodecyldimethylammonium bromide (DMAB), was absorbed on the NP surface by electrostatic attraction between positive and negative charges. NPs were characterized in such aspects as size, surface morphology, surface charges as well as in vitro drug release profile. Balloon injured rabbit carotid arteries were treated with single infusion of paclitaxel-loaded NP suspension and observed for 28 days. The inhibitory effects of NPs on neointima formation were evaluated as end-point. RESULTS: NPs showed spherical shape with a diameter ranging from 200 to 500 nm. Negatively charged PLGA NPs shifted to positive after the DMAB modification. The in vitro drug release profile showed a biphasic release pattern. Morphometric analyses on the retrieved artery samples revealed that the inhibitory effect of intima proliferation was dose-dependent. At a concentration of 30 mg ml(-1), NP infusion completely inhibited intima proliferation in a rabbit vascular injury model. CONCLUSIONS: Paclitaxel-loaded NPs with DMAB modification were proven an effective means of inhibiting proliferative response to vascular injury in a rabbit model.
Lin Mei; Hongfan Sun; Xu Jin; Dunwan Zhu; Rui Sun; Minfang Zhang; Cunxian Song
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-03-20
Journal Detail:
Title:  Pharmaceutical research     Volume:  24     ISSN:  0724-8741     ISO Abbreviation:  Pharm. Res.     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-04-26     Completed Date:  2007-10-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8406521     Medline TA:  Pharm Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  955-62     Citation Subset:  IM    
The Tianjin Key Laboratory of Biomaterial Research, Institute of Biomedical Engineering, Peking Union Medical College & Chinese Academy of Medical Sciences, Tianjin, 300192, China.
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MeSH Terms
Antineoplastic Agents, Phytogenic / administration & dosage,  chemistry,  therapeutic use
Balloon Dilatation / adverse effects*,  methods
Carotid Artery Injuries / etiology,  pathology,  prevention & control
Chromatography, High Pressure Liquid
Disease Models, Animal
Endothelium, Vascular / drug effects,  injuries,  pathology
Hyperplasia / etiology,  pathology,  prevention & control*
Microscopy, Electron, Transmission
Nanoparticles / chemistry*,  ultrastructure
Paclitaxel / administration & dosage,  chemistry,  therapeutic use*
Particle Size
Polyglactin 910 / chemistry
Polyvinyl Alcohol / chemistry
Time Factors
Treatment Outcome
Tunica Intima / drug effects,  injuries,  pathology
Reg. No./Substance:
0/Antineoplastic Agents, Phytogenic; 33069-62-4/Paclitaxel; 34346-01-5/Polyglactin 910; 9002-89-5/Polyvinyl Alcohol

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