| Modified paclitaxel-loaded nanoparticles for inhibition of hyperplasia in a rabbit arterial balloon injury model. | |
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MedLine Citation:
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PMID: 17372684 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: This study tested the possibility of localized intravascular infusion of positive charged paclitaxel-loaded nanoparticles (NPs) to better prevent neointimal formation in a rabbit carotid artery injury model. MATERIALS AND METHODS: NPs were prepared by oil-water emulsion/solvent evaporation technique using biodegradable poly (lactide-co-glycolide) (PLGA). A cationic surfactant, didodecyldimethylammonium bromide (DMAB), was absorbed on the NP surface by electrostatic attraction between positive and negative charges. NPs were characterized in such aspects as size, surface morphology, surface charges as well as in vitro drug release profile. Balloon injured rabbit carotid arteries were treated with single infusion of paclitaxel-loaded NP suspension and observed for 28 days. The inhibitory effects of NPs on neointima formation were evaluated as end-point. RESULTS: NPs showed spherical shape with a diameter ranging from 200 to 500 nm. Negatively charged PLGA NPs shifted to positive after the DMAB modification. The in vitro drug release profile showed a biphasic release pattern. Morphometric analyses on the retrieved artery samples revealed that the inhibitory effect of intima proliferation was dose-dependent. At a concentration of 30 mg ml(-1), NP infusion completely inhibited intima proliferation in a rabbit vascular injury model. CONCLUSIONS: Paclitaxel-loaded NPs with DMAB modification were proven an effective means of inhibiting proliferative response to vascular injury in a rabbit model. |
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Authors:
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Lin Mei; Hongfan Sun; Xu Jin; Dunwan Zhu; Rui Sun; Minfang Zhang; Cunxian Song |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-03-20 |
Journal Detail:
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Title: Pharmaceutical research Volume: 24 ISSN: 0724-8741 ISO Abbreviation: Pharm. Res. Publication Date: 2007 May |
Date Detail:
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Created Date: 2007-04-26 Completed Date: 2007-10-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8406521 Medline TA: Pharm Res Country: United States |
Other Details:
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Languages: eng Pagination: 955-62 Citation Subset: IM |
Affiliation:
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The Tianjin Key Laboratory of Biomaterial Research, Institute of Biomedical Engineering, Peking Union Medical College & Chinese Academy of Medical Sciences, Tianjin, 300192, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antineoplastic Agents, Phytogenic / administration & dosage, chemistry, therapeutic use Balloon Dilatation / adverse effects*, methods Carotid Artery Injuries / etiology, pathology, prevention & control Chromatography, High Pressure Liquid Diffusion Disease Models, Animal Endothelium, Vascular / drug effects, injuries, pathology Hyperplasia / etiology, pathology, prevention & control* Microscopy, Electron, Transmission Nanoparticles / chemistry*, ultrastructure Paclitaxel / administration & dosage, chemistry, therapeutic use* Particle Size Polyglactin 910 / chemistry Polyvinyl Alcohol / chemistry Rabbits Solubility Time Factors Treatment Outcome Tunica Intima / drug effects, injuries, pathology |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents, Phytogenic; 33069-62-4/Paclitaxel; 34346-01-5/Polyglactin 910; 9002-89-5/Polyvinyl Alcohol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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