Document Detail

Modified myocardial performance index for evaluation of fetal cardiac function in pre-eclampsia.
MedLine Citation:
PMID:  19086000     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess cardiac function by means of the modified myocardial performance index (Mod-MPI) in fetuses of pre-eclamptic mothers without intrauterine growth restriction and to compare this with values from normal controls. METHODS: A cross-sectional study was conducted including a total of 72 fetuses at between 26 and 40 weeks' gestation. Forty fetuses of healthy mothers were assigned as the control group (Group I) while 15 fetuses of mildly pre-eclamptic mothers constituted Group II and 17 fetuses of severely pre-eclamptic mothers constituted Group III. Two-dimensional gray-scale and Doppler fetal echocardiography was used to exclude cardiac anomalies and calculate the Mod-MPI. RESULTS: The mean+/-SD Mod-MPI values of Groups I, II and III were 0.43+/-0.045, 0.44+/-0.064 and 0.44+/-0.064, respectively (P=0.680). The mean aortic peak systolic velocity (PSV), the mean mitral valve early ventricular filling (E-wave) and active atrial filling (A-wave) peak velocities were significantly lower in fetuses of severely pre-eclamptic mothers than in fetuses of mildly pre-eclamptic mothers and control fetuses. CONCLUSION: The fetal global myocardial function assessed by Mod-MPI does not seem to change in mild or severe pre-eclampsia. The lower mitral E-wave and A-wave peak velocities and the lower aortic PSV seem to reflect the increased cardiac afterload against which the fetal heart has to work, rather than systolic or diastolic cardiac dysfunction, in the fetuses of severely pre-eclamptic mothers.
O Api; M Balcin Emeksiz; M Api; V Ugurel; O Unal
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology     Volume:  33     ISSN:  1469-0705     ISO Abbreviation:  Ultrasound Obstet Gynecol     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-01-05     Completed Date:  2009-09-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9108340     Medline TA:  Ultrasound Obstet Gynecol     Country:  England    
Other Details:
Languages:  eng     Pagination:  51-7     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2008 ISUOG.
Department of Obstetrics & Gynecology, Dr Lutfi Kirdar Kartal Teaching and Research Hospital Istanbul, Turkey.
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MeSH Terms
Cross-Sectional Studies
Fetal Heart / physiopathology*,  ultrasonography
Gestational Age
Placental Circulation / physiology*
Pre-Eclampsia / physiopathology*,  ultrasonography
Ultrasonography, Prenatal
Vascular Resistance / physiology*
Young Adult

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