| Modified metabolic responsiveness to glucagon in cold-acclimated and heat-acclimated rats. | |
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MedLine Citation:
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PMID: 7070233 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Calorigenic effect of glucagon on whole body oxygen consumption and interscapular brown adipose tissue (BAT) was investigated in unanesthetized and unrestrained warm controls (WC), cold-acclimated rats (CA) and heat-acclimated rats (HA). Glucagon produced significant elevation of oxygen consumption, body temperature and BAT temperature in all experimental groups. Such increased calorigenic responses to glucagon were significantly potentiated in CA and reduced in HA compared with those in WC. Thermogenic response of BAT to norepinephrine was also similar to that to glucagon; it was potentiated in CA, reduced in HA. These results indicate that glucagon would serve thermoregulatory nonshivering thermogenesis in temperature acclimation as calorigenic hormone, at least in part, through its action on BAT. |
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Authors:
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K Doi; A Kuroshima |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Life sciences Volume: 30 ISSN: 0024-3205 ISO Abbreviation: Life Sci. Publication Date: 1982 Mar |
Date Detail:
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Created Date: 1982-06-14 Completed Date: 1982-06-14 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0375521 Medline TA: Life Sci Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 785-91 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue, Brown
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drug effects,
metabolism Animals Body Temperature Regulation / drug effects* Cold Temperature* Glucagon / pharmacology* Hot Temperature* Male Norepinephrine / pharmacology Oxygen Consumption / drug effects Rats |
| Chemical | |
Reg. No./Substance:
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51-41-2/Norepinephrine; 9007-92-5/Glucagon |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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