| Modified hemoglobin solution as possible perfusate relevant to organ transplantation. | |
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MedLine Citation:
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PMID: 1391475 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A modified hemoglobin solution (<pyridoxylated hemoglobin>-<polyoxyethylene> conjugate solution, PHP solution) has very interesting characteristics such as oxygen-carrying property without corpuscular components. Experimental use of the PHP solution has shown promising possibilities as a perfusate relevant to organ transplantations. 1) Elongation of warm ischemic time in canine kidneys: Dogs survived even with the unilateral kidneys which had been exposed up to 4.5 hour warm ischemia and, thereafter, perfused with the PHP solution. 2) Elongation of perfusion preservation period of canine livers: Dogs survived with the transplanted livers which had been perfused for 48 hours with the PHP solution. 3) Successful perfusion of rat small intestine: Lewis rat intestines perfused and preserved for 12 hours with the PHP solution showed a higher survival rate compared with those with Collins or UW solution. 4) Removal of antibodies: By exchange transfusion with a total of 30-60 ml of the PHP solution, a Lewis rat hematocrit lowered to 5% while IgG went down to nil from 8970 mg/dl, IgA to 28 mg/dl from 118 mg/dl and IgM to 190 mg/dl from 897 mg/dl. This technique is expected to be applicable for removal of the naturally existing antibodies in xenotransplantation. |
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Authors:
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T Agishi; K Sonda; I Nakajima; S Fuchinoue; H Honda; H Suga; H Liu; S Teraoka; K Ota |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology Volume: 20 ISSN: 1055-7172 ISO Abbreviation: Biomater Artif Cells Immobilization Biotechnol Publication Date: 1992 |
Date Detail:
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Created Date: 1992-11-18 Completed Date: 1992-11-18 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9111988 Medline TA: Biomater Artif Cells Immobilization Biotechnol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 539-44 Citation Subset: IM |
Affiliation:
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Dept of Surgery, Tokyo Women's Medical College, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Substitutes* Dogs Evaluation Studies as Topic Hemoglobins* Organ Preservation Organ Transplantation* Perfusion Polyethylene Glycols* Rats Rats, Inbred Lew Solutions |
| Chemical | |
Reg. No./Substance:
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0/Blood Substitutes; 0/Hemoglobins; 0/Polyethylene Glycols; 0/Solutions; 0/pyridoxalated-hemoglobin-polyethylene glycol conjugate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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