| Modified exercise test in screening for mitochondrial myopathies--adjustment of workload in relation to muscle strength. | |
| | |
MedLine Citation:
|
PMID: 14631128 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The aim of this study was to evaluate the usefulness of a modification of the bicycle ergometer test, the subanaerobic threshold exercise test (SATET), as a screening test for patients with mitochondrial myopathies. Since the original SATET is frequently found to be strenuous for weak patients, a new variable (relative muscle strength) was added to the workload formula. Plasma lactate levels were recorded at rest, then after 5 and 15 min of cycling on an ergometer, with constant workload. Nine patients with mitochondrial myopathy, 10 patients with other neuromuscular diseases and 9 healthy but sedentary volunteers undertook the test. An upper reference limit after exercise for plasma lactate was settled at 2.9 mmol/l. The modified SATET showed a sensitivity of 78% and a specificity compared to the healthy subjects of 100%. Compared to patients with other neuromuscular diseases, the specificity was lower (60%). All subjects completed the test without severe fatigue or pain. |
| | |
Authors:
|
Elisabet Hammarén; Lena Rafsten; Margareta Kreuter; Christopher Lindberg |
Related Documents
:
|
22951598 - Effect of physical exercise training on muscle strength and body composition, and their... 8056678 - Influence of treadmill exercise on pituitary-adrenal secretions, other blood constituen... 18308878 - Heart rate-based protocols for exercise challenge testing do not ensure sufficient exer... 3416848 - Influence of a 24 h fast on high intensity cycle exercise performance in man. 8867778 - Different levels of sensory neuropeptides (calcitonin gene-related peptide and substanc... 9680658 - Exercise for female osteoporosis. a systematic review of randomised clinical trials. |
Publication Detail:
|
Type: Comparative Study; Journal Article Date: 2003-11-19 |
Journal Detail:
|
Title: European neurology Volume: 51 ISSN: 0014-3022 ISO Abbreviation: Eur. Neurol. Publication Date: 2004 |
Date Detail:
|
Created Date: 2003-12-19 Completed Date: 2004-02-27 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0150760 Medline TA: Eur Neurol Country: Switzerland |
Other Details:
|
Languages: eng Pagination: 38-41 Citation Subset: IM |
Copyright Information:
|
Copyright 2004 S. Karger AG, Basel |
Affiliation:
|
Neuromuscular Centre, Department of Neurology, Sahlgrenska University Hospital, Mölndal, Sweden. elisabet.hammaren@vgregion.se |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Case-Control Studies Exercise Test* / methods Exercise Tolerance Female Humans Lactic Acid / blood* Male Mass Screening / methods* Middle Aged Mitochondrial Myopathies / blood, diagnosis* Muscle, Skeletal / physiopathology* Neuromuscular Diseases / diagnosis Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
|
50-21-5/Lactic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Polymorphisms and Risk of Ischemic Stroke (POLARIS) study: rationale and design.
Next Document: Giant colonic diverticula. Review of diagnostic and therapeutic options.