Document Detail

Modified exercise test in screening for mitochondrial myopathies--adjustment of workload in relation to muscle strength.
MedLine Citation:
PMID:  14631128     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to evaluate the usefulness of a modification of the bicycle ergometer test, the subanaerobic threshold exercise test (SATET), as a screening test for patients with mitochondrial myopathies. Since the original SATET is frequently found to be strenuous for weak patients, a new variable (relative muscle strength) was added to the workload formula. Plasma lactate levels were recorded at rest, then after 5 and 15 min of cycling on an ergometer, with constant workload. Nine patients with mitochondrial myopathy, 10 patients with other neuromuscular diseases and 9 healthy but sedentary volunteers undertook the test. An upper reference limit after exercise for plasma lactate was settled at 2.9 mmol/l. The modified SATET showed a sensitivity of 78% and a specificity compared to the healthy subjects of 100%. Compared to patients with other neuromuscular diseases, the specificity was lower (60%). All subjects completed the test without severe fatigue or pain.
Elisabet Hammarén; Lena Rafsten; Margareta Kreuter; Christopher Lindberg
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2003-11-19
Journal Detail:
Title:  European neurology     Volume:  51     ISSN:  0014-3022     ISO Abbreviation:  Eur. Neurol.     Publication Date:  2004  
Date Detail:
Created Date:  2003-12-19     Completed Date:  2004-02-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0150760     Medline TA:  Eur Neurol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  38-41     Citation Subset:  IM    
Copyright Information:
Copyright 2004 S. Karger AG, Basel
Neuromuscular Centre, Department of Neurology, Sahlgrenska University Hospital, Mölndal, Sweden.
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MeSH Terms
Case-Control Studies
Exercise Test* / methods
Exercise Tolerance
Lactic Acid / blood*
Mass Screening / methods*
Middle Aged
Mitochondrial Myopathies / blood,  diagnosis*
Muscle, Skeletal / physiopathology*
Neuromuscular Diseases / diagnosis
Sensitivity and Specificity
Reg. No./Substance:
50-21-5/Lactic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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