Document Detail

Modified cold pressor test by cold application to the foot after spinal cord injury: suggestion of hemodynamic control by the spinal cord.
MedLine Citation:
PMID:  18049135     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Study hemodynamic responses to cold application to the foot (CAF) to explore the autonomic cardiovascular control by the spinal cord. DESIGN: Controlled experimental study. Hemodynamic variables were measured or calculated for 13 healthy subjects, 10 patients with traumatic T4-T6 paraplegia, and 11 patients with traumatic C4-C7 tetraplegia. Subjects were continuously monitored for heart rate (HR), blood pressure (BP), and cerebral blood-flow velocity (CBFV) from 5 mins before to 5 mins after 40-120 secs of CAF by ice water foot immersion. The recorded signals were digitized online and analyzed offline in the time and frequency domains. RESULTS: During CAF, HR increased in the control group but decreased in patients (P < 0.001). BP increased significantly in the control and tetraplegia groups (P < 0.001) and nonsignificantly in the paraplegia group. HR and BP spectral components (LF, HF, LF/HF) did not change significantly. CBFV increased significantly in the patient groups (P < 0.05) but not in the control subjects. The cerebrovascular resistance increased significantly in the control and tetraplegia groups (P < 0.001), but not in the paraplegia group. CONCLUSIONS: The findings support the presence of hemodynamic autonomic control by the spinal cord and show that responses to CAF can be used to assess its integrity.
A Catz; V Bluvshtein; A D Korczyn; I Pinhas; I Gelernter; T Nissel; Y Vered; N M Bornstein; S Akselrod
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of physical medicine & rehabilitation / Association of Academic Physiatrists     Volume:  86     ISSN:  0894-9115     ISO Abbreviation:  Am J Phys Med Rehabil     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-11-30     Completed Date:  2008-01-03     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8803677     Medline TA:  Am J Phys Med Rehabil     Country:  United States    
Other Details:
Languages:  eng     Pagination:  875-82     Citation Subset:  AIM; IM    
Loewenstein Rehabilitation Hospital, Raanana, Israel.
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MeSH Terms
Autonomic Dysreflexia / physiopathology
Cerebrovascular Circulation / physiology
Cold Temperature*
Paraplegia / rehabilitation*
Quadriplegia / rehabilitation*
Spinal Cord / physiology
Spinal Cord Injuries / physiopathology*

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