Document Detail


Modified Titanium Surfaces Alter Osteogenic Differentiation; a Comparative Microarray-Based Analysis of Human Mesenchymal Cell Response to Commercial Titanium Surfaces.
MedLine Citation:
PMID:  21554083     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract ABSTRACTThe differential effects of dual-acid etched (Osseotite®), hydroxyapatite coated (HA®) and sand-blasted/acid-etched (SLA®) titanium surfaces on human bone marrow-derived mesenchymal cells (hMSCs) were investigated. Proliferation was significantly promoted on the SLA surfaces. 16 genes were significantly upregulated when hMSCs were cultured on the Osseotite® and the HA® surfaces and 15 genes on the SLA surfaces. Upregulated genes control cell differentiation, signal transduction, cell cycle regulation, angiogenesis, cell adhesion and extracellular matrix and bone formation.
Authors:
Anastasios Mamalis; Spyridon Silvestros
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-5-9
Journal Detail:
Title:  The Journal of oral implantology     Volume:  -     ISSN:  0160-6972     ISO Abbreviation:  -     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-5-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7801086     Medline TA:  J Oral Implantol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
UTHSCSA, PERIODONTICS, UTHSCSA.
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