| Modified phenazines from an Indonesian Streptomyces sp. | |
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MedLine Citation:
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PMID: 20092333 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fractionation of the extract from the Indonesian Streptomyces sp. ICBB8198 as directed by the antibacterial activity delivered the known phenazine antibiotics griseoluteic acid (1a) and griseolutein A (1b), as well as two new phenazine derivatives (2 and 3). In addition, the known compounds spirodionic acid, dihydrosarkomycins, and 6-ethyl-4-hydroxy-3,5-dimethyl-2H-pyran-2-one (4a), along with the new pyrone 3,6-diethyl-4-hydroxy-5-methyl-2H-pyran-2-one (4b), were isolated. We report here the isolation, structure elucidation, and antibiotic activity of the new metabolites as well as a hypothetical pathway for the formation of the new phenazine derivatives. |
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Authors:
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Serge Fotso; Dwi Andreas Santosa; Rasti Saraswati; Jongtae Yang; Taifo Mahmud; T Mark Zabriskie; Philip J Proteau |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of natural products Volume: 73 ISSN: 1520-6025 ISO Abbreviation: J. Nat. Prod. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-26 Completed Date: 2010-04-30 Revised Date: 2012-10-09 |
Medline Journal Info:
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Nlm Unique ID: 7906882 Medline TA: J Nat Prod Country: United States |
Other Details:
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Languages: eng Pagination: 472-5 Citation Subset: IM |
Affiliation:
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Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, Oregon 97331-3507, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bacillus subtilis
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drug effects Candida albicans / drug effects Escherichia coli / drug effects Indonesia Microbial Sensitivity Tests Molecular Structure Mucor / drug effects Phenazines / chemistry, isolation & purification* Pseudomonas aeruginosa / drug effects Staphylococcus aureus / drug effects Streptomyces / chemistry, isolation & purification* |
| Grant Support | |
ID/Acronym/Agency:
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ES00210/ES/NIEHS NIH HHS; P30 ES000210/ES/NIEHS NIH HHS; P30 ES000210-41S1/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Phenazines |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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