Document Detail


Modified LDL - trigger of atherosclerosis and inflammation in the arterial intima.
MedLine Citation:
PMID:  10762453     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Atherosclerosis is characterized by chronic inflammation of an injured intima. The pathological processes are initiated by accumulation of morphologically distinct, modified forms of LDL, and followed by cellular infiltration and foam cell formation. Activated intimal cells secrete enzymes and agents capable of modifying LDL, and the modified lipids of LDL, in turn, are able to activate intimal cells and to trigger various inflammatory signals. These processes can initiate and maintain a vicious circle in the intima and lead to lesion progression. In this review, we focus on the LDL modifications relevant to the initial lipid accumulation and discuss their pro-inflammatory effects.
Authors:
M O Pentikäinen; K Oörni; M Ala-Korpela; P T Kovanen
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of internal medicine     Volume:  247     ISSN:  0954-6820     ISO Abbreviation:  J. Intern. Med.     Publication Date:  2000 Mar 
Date Detail:
Created Date:  2000-05-12     Completed Date:  2000-05-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8904841     Medline TA:  J Intern Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  359-70     Citation Subset:  IM    
Affiliation:
Wihuri Research Institute, Helsinki, Finland.
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MeSH Terms
Descriptor/Qualifier:
Arteriosclerosis / blood*,  etiology*
Cholesterol, LDL / blood*
Humans
Inflammation
Tunica Intima / injuries,  metabolism*
Chemical
Reg. No./Substance:
0/Cholesterol, LDL

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