Document Detail

Modified DNA analogues that sense light exposure with color changes.
MedLine Citation:
PMID:  15469249     Owner:  NLM     Status:  MEDLINE    
We report the discovery of a new class of light-sensing molecules. These light sensors are composed of fluorophore oligomers assembled on a DNA backbone. A combinatorial library of tetrafluorophores consisting of over 14 000 compounds was synthesized and screened for rapid responses toward light exposure. Among the most light-sensitive molecules, at least three tetramers were found to respond to light exposure with apparent color changes, rather than simple photobleaching.
Jianmin Gao; Soichiro Watanabe; Eric T Kool
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of the American Chemical Society     Volume:  126     ISSN:  0002-7863     ISO Abbreviation:  J. Am. Chem. Soc.     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-10-07     Completed Date:  2005-04-14     Revised Date:  2008-01-17    
Medline Journal Info:
Nlm Unique ID:  7503056     Medline TA:  J Am Chem Soc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  12748-9     Citation Subset:  IM    
Department of Chemistry, Stanford University, Stanford, CA 94305-5080, USA.
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MeSH Terms
Combinatorial Chemistry Techniques
DNA / chemistry*,  radiation effects*
Deoxyribonucleosides / chemical synthesis,  chemistry
Fluorescent Dyes / chemical synthesis,  chemistry
Glycosides / chemistry
Oligonucleotides / chemical synthesis,  chemistry,  radiation effects
Spectrometry, Fluorescence / methods*
Grant Support
Reg. No./Substance:
0/Deoxyribonucleosides; 0/Fluorescent Dyes; 0/Glycosides; 0/Oligonucleotides; 9007-49-2/DNA

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