Document Detail


Modifications of ultradian and circadian rhythms of fetal heart rate after fetal-maternal adrenal gland suppression: a double blind study.
MedLine Citation:
PMID:  3809112     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In order to verify whether fetal and maternal adrenal gland suppression induces effects on fetal behaviour, triamcinolone was administered to five healthy pregnant women at 35 weeks of gestation. Five patients of the same gestational age were used as control. Fetal heart rate (FHR) and fetal movements were recorded continuously over 2-h interval by means of cardiotocography. After 3 weeks (38 weeks of gestation) the recordings were repeated without drug administration. Cortisol, adrenocorticotropin hormone, 17 beta-estradiol and unconjugated estriol were measured at the same time every 2 h in maternal peripheral plasma. At 35 weeks we found a loss of circadian rhythms of the hormones investigated and modifications of ultradian and circadian patterns of FHR in the treated group with respect to the control. No differences in hormonal and biophysical parameters were found between the two groups after the end of treatment (38 weeks). These data suggest that the inhibition of fetal and maternal adrenal glands could cause modifications of FHR patterns.
Authors:
D Arduini; G Rizzo; E Parlati; C Giorlandino; H Valensise; S Dell'Acqua; C Romanini
Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Prenatal diagnosis     Volume:  6     ISSN:  0197-3851     ISO Abbreviation:  Prenat. Diagn.     Publication Date:    1986 Nov-Dec
Date Detail:
Created Date:  1987-03-04     Completed Date:  1987-03-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  409-17     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Activity Cycles
Circadian Rhythm* / drug effects
Double-Blind Method
Female
Fetal Heart / drug effects,  physiology*
Fetal Movement* / drug effects
Heart Rate / drug effects
Humans
Hydrocortisone / physiology*
Pregnancy
Triamcinolone / pharmacology*
Chemical
Reg. No./Substance:
124-94-7/Triamcinolone; 50-23-7/Hydrocortisone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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