| Modifications to the McDonald MRI dissemination in space criteria for use in Asians with classic multiple sclerosis: the Taiwanese experience. | |
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MedLine Citation:
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PMID: 20670986 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The McDonald MRI dissemination in space criteria have been found to be less sensitive when applied to Asians with classic multiple sclerosis. The Asian neurological community thus proposed modifications to the criteria with reduction of minimal number of T2 lesions from nine to four, and removal of restriction on spinal cord lesion length and morphology for use in Asians. OBJECTIVE: The study is to examine the accuracy of modified MRI dissemination in space criteria for prediction of conversion from clinically isolated syndrome to definite multiple sclerosis according to patients' baseline MRI. METHODS: From 2001 to 2007, we recruited 67 patients with clinically isolated syndrome. They had been followed-up until development of definite multiple sclerosis or remaining as clinically isolated syndrome for more than 2 years. The non-converters were taken as negative cases. The 67 patients' baseline MRIs were evaluated by two radiologists and determined as either fulfilling or not fulfilling McDonald and modified MRI criteria for dissemination in space. RESULTS: Thirty-two patients converted to definite multiple sclerosis and 35 did not. The modified criteria are slightly more sensitive (53.1% vs. 50.0%) and accurate (77.6% vs. 76.1%) as compared with McDonald criteria. However, further reduction of the cutoff of abnormal MRI criteria from three of four to two of four criteria yields best sensitivity (71.9%) and accuracy (83.6%). CONCLUSIONS: Modifications to the McDonald MRI dissemination in space criteria (by using fewer T2 lesions, removal of the restriction on the spinal cord lesion and reduction of the cutoff of MRI criteria) are more appropriate for use in the Taiwanese population for the diagnosis of classic multiple sclerosis. |
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Authors:
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Shao-Yuan Chen; Chung-Ping Lo; Wen-Lin Hsu; Hung-Wen Kao; Chun-Jen Hsueh; Wei-Chen Lin; Chia-Chen Liu; Wei-Yu Wang; Chia-Chun Hsu |
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Publication Detail:
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Type: Journal Article Date: 2010-07-29 |
Journal Detail:
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Title: Multiple sclerosis (Houndmills, Basingstoke, England) Volume: 16 ISSN: 1477-0970 ISO Abbreviation: Mult. Scler. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-04 Completed Date: 2011-01-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9509185 Medline TA: Mult Scler Country: England |
Other Details:
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Languages: eng Pagination: 1213-9 Citation Subset: IM |
Affiliation:
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Department of Neurology and Hyperbaric Medicine, Cardinal Tien Hospital, Taipei, Taiwan. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Asian Continental Ancestry Group Brain / pathology Cohort Studies Contrast Media Disease Progression Female Gadolinium DTPA / diagnostic use Humans Image Processing, Computer-Assisted / methods* Magnetic Resonance Imaging / methods* Male Middle Aged Multiple Sclerosis / pathology*, therapy Spinal Cord / pathology Taiwan Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 80529-93-7/Gadolinium DTPA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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