Document Detail

Modifications of intra- and extracellular sodium and potassium. A possible mechanism for the antihypertensive action of captopril and hydrochlorothiazide.
MedLine Citation:
PMID:  2856785     Owner:  NLM     Status:  MEDLINE    
Forty-four essential hypertensive patients were studied during placebo and after 2 months of the following treatments: hydrochlorothiazide 25 mg once daily (group 1); captopril 50 mg twice daily (group 2); hydrochlorothiazide + captopril (group 3). Blood pressure, serum sodium and potassium (Nae, Ke) and intralymphocytic sodium and potassium (Nai, Ki) were measured before and after treatment. During placebo, diastolic blood pressure was directly related to Nai (r = -0.84) and inversely related to Ki (r = -0.81). The correlation was even greater when the Ki:Ke ratio was considered instead of Ki alone (r = -0.91). Hydrochlorothiazide reduced Nai, Ke and Ki. Captopril induced a decrease in Nai, an increase in Ki and no change in Nae or Ke. The association of the two drugs caused a reduction in Nae and Nai and an increase in Ki. All three treatments caused an increase in Ki:Ke ratio which was proportional to the decrease in the blood pressure. While the antihypertensive effect of hydrochlorothiazide seems to be more related to Nai:Nae reduction, the effect of captopril seems to be more related to the increase in Ki:Ke ratio. The results of our study suggest that hyperpolarization of arterial smooth muscle cells, induced by a Ki:Ke ratio increase, along with a reduction in Nai:Nae, might play a role in the antihypertensive effect of captopril and hydrochlorothiazide.
E Ambrosioni; F V Costa; C Borghi; A Mussi; S Boschi
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of hypertension. Supplement : official journal of the International Society of Hypertension     Volume:  3     ISSN:  0952-1178     ISO Abbreviation:  J Hypertens Suppl     Publication Date:  1985 Dec 
Date Detail:
Created Date:  1993-08-31     Completed Date:  1993-08-31     Revised Date:  2005-06-08    
Medline Journal Info:
Nlm Unique ID:  8501422     Medline TA:  J Hypertens Suppl     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  S69-71     Citation Subset:  IM    
Cattedra e Servizio di Farmacologia Clinica, Policlinico S. Orsola, Università di Bologna, Italy.
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MeSH Terms
Antihypertensive Agents / pharmacology*,  therapeutic use
Captopril / pharmacology*,  therapeutic use
Drug Therapy, Combination
Hydrochlorothiazide / pharmacology*,  therapeutic use
Hypertension / drug therapy,  metabolism*
Middle Aged
Potassium / blood,  metabolism*
Sodium / blood,  metabolism*
Reg. No./Substance:
0/Antihypertensive Agents; 58-93-5/Hydrochlorothiazide; 62571-86-2/Captopril; 7440-09-7/Potassium; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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