| Modifications in dietary fat quality are associated with changes in serum lipids of older adults independently of lipid medication. | |
| | |
MedLine Citation:
|
PMID: 19923396 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Prospective evidence on the extent to which serum lipid concentrations in older persons respond to dietary modification is scarce. It is not clear whether such behavioral changes are relevant in the context of more commonly initiated treatments with lipid-lowering drugs. We therefore examined whether individual changes in the consumption of dietary fatty acids or main food sources were associated with changes in the serum lipid profile of older Australians. A total of 903 participants (> or =49 y) in the Blue Mountains Eye Study had complete data on fasting lipids and dietary intake from a validated FFQ at baseline (1992-1994) and 5- and 10-y follow-up examinations. Decreasing consumption of SFA and butter during the 10-y period were associated with moderate decreases in serum total cholesterol independently of initiation of lipid-lowering drug treatment [adjusted estimates were 0.018 +/- 0.007 mmol/(L x % energy (%en) from SFA (P = 0.01) and 0.055 +/- 0.015 mmol/(L x 5 g butter) (P = 0.0003), respectively]. Increased consumption of (n-3) fatty acids and fish was independently related to modest increases in serum HDL-cholesterol [0.067 +/- 0.026 mmol/(L x %en from (n-3) fatty acids) (P = 0.01) and 0.010 +/- 0.004 mmol/(L x 20 g fish) (P = 0.02)] and decreases in log-transformed serum triglyceride concentrations [P = 0.02 for (n-3) fatty acids and P = 0.02 for fish intake]. Hence, 10-y changes in the intake of dietary fatty acids and their food sources appear to have contributed to concurrent improvements in the serum lipid profile of older Australians, independent of concomitantly initiated lipid-lowering drug treatment. |
| | |
Authors:
|
Anette E Buyken; Victoria Flood; Elena Rochtchina; Paul Nestel; Jennie Brand-Miller; Paul Mitchell |
Related Documents
:
|
2403586 - Efficacy of fish oil supplementation for treatment of moderate elevation of serum chole... 9481526 - A diet rich in walnuts favourably influences plasma fatty acid profile in moderately hy... 20402316 - Are lipoprotein disturbances in chronic hemodialyzed patients only renal failure related? 15523486 - Veganism and its relationship with insulin resistance and intramyocellular lipid. 2510556 - Effect of simultaneous local injection of 6-hydroxydopamine and naloxone on the testis ... 12449286 - Results of an adjunct dietary intervention program in the women's health initiative. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-11-18 |
Journal Detail:
|
Title: The Journal of nutrition Volume: 140 ISSN: 1541-6100 ISO Abbreviation: J. Nutr. Publication Date: 2010 Jan |
Date Detail:
|
Created Date: 2009-12-21 Completed Date: 2010-01-21 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0404243 Medline TA: J Nutr Country: United States |
Other Details:
|
Languages: eng Pagination: 88-94 Citation Subset: IM |
Affiliation:
|
Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute, Sydney 2006, Australia. buyken@fke-do.de |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Antilipemic Agents
/
therapeutic use* Butter Cohort Studies Dietary Fats / pharmacology* Fatty Acids Fatty Acids, Unsaturated Female Food Habits Humans Hyperlipidemias / blood, drug therapy* Lipids / blood* Male Middle Aged |
| Chemical | |
Reg. No./Substance:
|
0/Antilipemic Agents; 0/Dietary Fats; 0/Fatty Acids; 0/Fatty Acids, Unsaturated; 0/Lipids; 8029-34-3/Butter |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Castel Gandolfo Workshop: An Introduction to the Impact of Climate Change, the Economic Crisis, and ...
Next Document: Dietary Plasma Protein Supplements Prevent the Release of Mucosal Proinflammatory Mediators in Intes...